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Scientific article
English

AS601245, a c-Jun NH2-terminal kinase (JNK) inhibitor, reduces axon/dendrite damage and cognitive deficits after global cerebral ischaemia in gerbils

Published inBritish journal of pharmacology, vol. 153, no. 1, p. 157-163
Publication date2008
Abstract

Based on their proven ability, in animal models of stroke, to reduce damage to brain grey matter, many drugs have been tested in clinical trials but without success. Failure to save axons from injury and to protect functional outcome has been proposed as the major reason for this lack of success. We have previously demonstrated in two rodent models of cerebral ischaemia, that AS601245 (1,3-benzothiazol-2-yl (2-([2-(3-pyridinyl) ethyl] amino)-4 pyrimidinyl) acetonitrile), an inhibitor of the c-Jun NH(2)-terminal kinase (JNK), has neuroprotective properties. The aim of the present study was to further investigate if AS601245 in addition to its ability to protect neurons also could protect neurites and preserve memory after cerebral ischaemia, in gerbils.

Keywords
  • Acetonitriles/pharmacology
  • Animals
  • Axons/drug effects/pathology
  • Benzothiazoles/pharmacology
  • Brain Ischemia/drug therapy/pathology
  • Cognition Disorders/prevention & control
  • Dendrites/drug effects/pathology
  • Gerbillinae
  • Hippocampus/drug effects/pathology
  • JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors
  • Male
  • Memory/drug effects
  • Neuroprotective Agents/pharmacology
  • Protein Kinase Inhibitors/pharmacology
Affiliation Not a UNIGE publication
Citation (ISO format)
CARBONI, Sonia et al. AS601245, a c-Jun NH2-terminal kinase (JNK) inhibitor, reduces axon/dendrite damage and cognitive deficits after global cerebral ischaemia in gerbils. In: British journal of pharmacology, 2008, vol. 153, n° 1, p. 157–163. doi: 10.1038/sj.bjp.0707574
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Article (Published version)
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ISSN of the journal0007-1188
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