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Title

AS601245, a c-Jun NH2-terminal kinase (JNK) inhibitor, reduces axon/dendrite damage and cognitive deficits after global cerebral ischaemia in gerbils

Authors
Boschert, U
Gaillard, P
Gotteland, J-P
Gillon, J-Y
Vitte, P-A
Published in British Journal of Pharmacology. 2008, vol. 153, no. 1, p. 157-163
Abstract Based on their proven ability, in animal models of stroke, to reduce damage to brain grey matter, many drugs have been tested in clinical trials but without success. Failure to save axons from injury and to protect functional outcome has been proposed as the major reason for this lack of success. We have previously demonstrated in two rodent models of cerebral ischaemia, that AS601245 (1,3-benzothiazol-2-yl (2-([2-(3-pyridinyl) ethyl] amino)-4 pyrimidinyl) acetonitrile), an inhibitor of the c-Jun NH(2)-terminal kinase (JNK), has neuroprotective properties. The aim of the present study was to further investigate if AS601245 in addition to its ability to protect neurons also could protect neurites and preserve memory after cerebral ischaemia, in gerbils.
Keywords Acetonitriles/pharmacologyAnimalsAxons/drug effects/pathologyBenzothiazoles/pharmacologyBrain Ischemia/drug therapy/pathologyCognition Disorders/prevention & controlDendrites/drug effects/pathologyGerbillinaeHippocampus/drug effects/pathologyJNK Mitogen-Activated Protein Kinases/antagonists & inhibitorsMaleMemory/drug effectsNeuroprotective Agents/pharmacologyProtein Kinase Inhibitors/pharmacology
Identifiers
PMID: 18026128
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(ISO format)
CARBONI, Sonia et al. AS601245, a c-Jun NH2-terminal kinase (JNK) inhibitor, reduces axon/dendrite damage and cognitive deficits after global cerebral ischaemia in gerbils. In: British Journal of Pharmacology, 2008, vol. 153, n° 1, p. 157-163. https://archive-ouverte.unige.ch/unige:89899

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Deposited on : 2016-12-06

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