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Dysthyroïdies liées à une surcharge iodée

Published in Revue médicale suisse. 2016, vol. 12, no. 515, p. 804-9
Abstract The principle sources of iodine overload, amiodarone and radiologic contrast media, are frequently used in modern medicine. The thyroid gland exerts a protective effect against iodine excess by suppressing iodine internalization into the thyrocyte and iodine organification, the Wolff-Chaikoff effect. Insufficiency of this effect or lack of escape from it leads to hypo- or hyperthyroidism respectively. Amiodarone induced thyrotoxicosis is a complex condition marked by two different pathophysiological mechanisms with different treatments. Thyroid metabolism changes after exposure to radiologic contrast media are frequent, but they rarely need to be treated. High risk individuals need to be identifed in order to delay the exam or to monitor thyroid function or apply prophylactic measures in selected cases.
Keywords Amiodarone/adverse effectsAnti-Arrhythmia Agents/adverse effectsAntithyroid Agents/therapeutic useContrast Media/adverse effectsHumansHyperthyroidism/chemically inducedHypothyroidism/chemically inducedIodine/administration & dosage/adverse effects/deficiencyTachycardia/drug therapyThyrotoxicosis/chemically induced/drug therapyTreatment Outcome
PMID: 27276725
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Research group Diabète et régulation des gènes (36)
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EGLOFF, Michaël, PHILIPPE, Jacques. Dysthyroïdies liées à une surcharge iodée. In: Revue médicale suisse, 2016, vol. 12, n° 515, p. 804-9. https://archive-ouverte.unige.ch/unige:89808

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Deposited on : 2016-12-02

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