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Scientific article
English

Multimodal imaging in Alzheimer's disease: validity and usefulness for early detection

Contributors

Teipel, Stefan; Drzezga, Alexander; Grothe, Michel J; Barthel, Henryk; Chételat, Gaël; Schuff, Norbert; Skudlarski, Pawel; Cavedo, Enrica; Frisoni, Giovanni; Hoffmann, Wolfgang; Thyrian, Jochen René; Fox, Chris; Minoshima, Satoshi; Sabri, Osama; Fellgiebel, Andreas

Published in

Lancet neurology, vol. 14, no. 10, p. 1037-1053

Publication date

2015

Abstract

Alzheimer's disease is a progressive neurodegenerative disease that typically manifests clinically as an isolated amnestic deficit that progresses to a characteristic dementia syndrome. Advances in neuroimaging research have enabled mapping of diverse molecular, functional, and structural aspects of Alzheimer's disease pathology in ever increasing temporal and regional detail. Accumulating evidence suggests that distinct types of imaging abnormalities related to Alzheimer's disease follow a consistent trajectory during pathogenesis of the disease, and that the first changes can be detected years before the disease manifests clinically. These findings have fuelled clinical interest in the use of specific imaging markers for Alzheimer's disease to predict future development of dementia in patients who are at risk. The potential clinical usefulness of single or multimodal imaging markers is being investigated in selected patient samples from clinical expert centres, but additional research is needed before these promising imaging markers can be successfully translated from research into clinical practice in routine care.

Keywords

  • Alzheimer Disease/diagnosis
  • Biomarkers
  • Early Diagnosis
  • Humans
  • Magnetic Resonance Imaging/standards
  • Multimodal Imaging/standards
  • Positron-Emission Tomography/standards

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

TEIPEL, Stefan et al. Multimodal imaging in Alzheimer’s disease: validity and usefulness for early detection. In: Lancet neurology, 2015, vol. 14, n° 10, p. 1037–1053. doi: 10.1016/S1474-4422(15)00093-9

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1474-4422
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Technical informations

Creation

21/11/2016 18:51:00

First validation

21/11/2016 18:51:00

Update

15/03/2023 01:03:36

Status update

15/03/2023 01:03:35

Last indexation

31/10/2024 05:21:12
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