Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia

Bocchetta, Martina; Gordon, Elizabeth; Manning, Emily; Barnes, Josephine; Cash, David M; Espak, Miklos; Thomas, David L; Modat, Marc; Rossor, Martin N; Warren, Jason D; Ourselin, Sebastien; Frisoni, Giovanni; Rohrer, Jonathan D

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Title		Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia
Authors		Bocchetta, Martina Gordon, Elizabeth Manning, Emily Barnes, Josephine Cash, David M Espak, Miklos Thomas, David L Modat, Marc Rossor, Martin N Warren, Jason D Ourselin, Sebastien Frisoni, Giovanni Rohrer, Jonathan D show all authors [1 - 13]
Published in		Journal of Neurology. 2015, vol. 262, no. 12, p. 2635-2642
Abstract		Abnormal eating behaviors are frequently reported in behavioral variant frontotemporal dementia (bvFTD). The hypothalamus is the regulatory center for feeding and satiety but its involvement in bvFTD has not been fully clarified, partly due to its difficult identification on MR images. We measured hypothalamic volume in 18 patients with bvFTD (including 9 MAPT and 6 C9orf72 mutation carriers) and 18 cognitively normal controls using a novel optimized multimodal segmentation protocol, combining 3D T1 and T2-weighted 3T MRIs (intrarater intraclass correlation coefficients ≥0.93). The whole hypothalamus was subsequently segmented into five subunits: the anterior (superior and inferior), tuberal (superior and inferior), and posterior regions. The presence of abnormal eating behavior was assessed with the revised version of the Cambridge Behavioural Inventory (CBI-R). The bvFTD group showed a 17% lower hypothalamic volume compared with controls (p < 0.001): mean 783 (standard deviation 113) versus 944 (73) mm(3) (corrected for total intracranial volume). In the hypothalamic subunit analysis, the superior parts of the anterior and tuberal regions and the posterior region were significantly smaller in the bvFTD group compared with controls. There was a trend for a smaller hypothalamic volume, particularly in the superior tuberal region, in those with severe eating disturbance scores on the CBI-R. Differences were seen between the two genetic subgroups with significantly smaller volumes in the MAPT but not the C9orf72 group compared with controls. In summary, bvFTD patients had lower hypothalamic volumes compared with controls. Different genetic mutations may have a differential impact on the hypothalamus.
Keywords		Adult — Aged — Feeding and Eating Disorders/etiology/physiopathology — Female — Frontotemporal Dementia/complications/genetics/pathology/physiopathology — Humans — Hypothalamus/pathology — Magnetic Resonance Imaging — Male — Middle Aged
Identifiers		DOI: 10.1007/s00415-015-7885-2 PMID: 26338813
Full text		Article (Author postprint) (559 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Research group		Troubles de mémoire et maladie d'Alzeimer (935)
Citation (ISO format)		BOCCHETTA, Martina et al. Detailed volumetric analysis of the hypothalamus in behavioral variant frontotemporal dementia. In: Journal of Neurology, 2015, vol. 262, n° 12, p. 2635-2642. https://archive-ouverte.unige.ch/unige:89742