UNIGE document Scientific Article
previous document  unige:89740  next document
add to browser collection
Title

Endpoints for Pre-Dementia AD Trials: A Report from the EU/US/CTAD Task Force

Authors
Vellas, B
Bateman, R
Blennow, K
Johnson, K
Katz, R
Langbaum, J
Marson, D
show hidden authors show all authors [1 - 13]
Published in The Journal of Prevention of Alzheimer's Disease. 2015, vol. 2, no. 2, p. 128-135
Abstract For Alzheimer's disease treatment trials that focus on the pre-dementia stage of disease, outcome measures are needed that will enable assessment of disease progression in patients who are clinically normal. The EU/US CTAD Task Force, an international collaboration of investigators from industry, academia, non-profit foundations, and regulatory agencies, met in Philadelphia, Pennsylvania, USA, on November 19, 2014 to discuss existing and novel outcome assessments that may be useful in pre-dementia trials. Composite measures that assess changes in episodic memory, executive function, global cognition, and global function have recently been developed by a number of groups and appear to be sensitive at this stage. Functional measures that involve real-life complex tasks also appear to capture early subtle changes in pre-dementia subjects and have the advantage of representing clinically meaningful change. Patient reported outcomes and novel CSF and imaging biomarkers have also shown promise. More studies are needed to validate all of these tests in the pre-dementia population. Many of them have been incorporated as exploratory measures in ongoing or planned trials.
Identifiers
PMID: 26247004
Full text
Article (Author postprint) (182 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Troubles de mémoire et maladie d'Alzeimer (935)
Citation
(ISO format)
VELLAS, B et al. Endpoints for Pre-Dementia AD Trials: A Report from the EU/US/CTAD Task Force. In: The Journal of Prevention of Alzheimer's Disease, 2015, vol. 2, n° 2, p. 128-135. https://archive-ouverte.unige.ch/unige:89740

48 hits

0 download

Update

Deposited on : 2016-12-02

Export document
Format :
Citation style :