en
Scientific article
Open access
English

The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing

Published inBMC biology, vol. 14, 69
Publication date2016
Abstract

After viral infection and the stimulation of some pattern-recognition receptors, TANK-binding kinase I (TBK1) is activated by K63-linked polyubiquitination followed by trans-autophosphorylation. While the activated TBK1 induces type I interferon production by phosphorylating the transcription factor IRF3, the precise molecular mechanisms underlying TBK1 activation remain unclear.

Citation (ISO format)
POURCELOT, Marie et al. The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing. In: BMC biology, 2016, vol. 14, p. 69. doi: 10.1186/s12915-016-0292-z
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1741-7007
437views
231downloads

Technical informations

Creation10/19/2016 10:55:00 AM
First validation10/19/2016 10:55:00 AM
Update time03/15/2023 1:03:16 AM
Status update03/15/2023 1:03:15 AM
Last indexation01/16/2024 10:31:41 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack