The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing

Pourcelot, Marie; Zemirli, Naima; Silva Da Costa, Leandro; Loyant, Roxane; Garcin, Dominique; Vitour, Damien; Munitic, Ivana; Vazquez, Aimé; Arnoult, Damien

doi:10.1186/s12915-016-0292-z

Scientific article

English

The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing

ContributorsPourcelot, Marie; Zemirli, Naima; Silva Da Costa, Leandro; Loyant, Roxane; Garcin, Dominique; Vitour, Damien; Munitic, Ivana; Vazquez, Aimé; Arnoult, Damien

Published inBMC biology, vol. 14, 69

Publication date2016

Abstract

After viral infection and the stimulation of some pattern-recognition receptors, TANK-binding kinase I (TBK1) is activated by K63-linked polyubiquitination followed by trans-autophosphorylation. While the activated TBK1 induces type I interferon production by phosphorylating the transcription factor IRF3, the precise molecular mechanisms underlying TBK1 activation remain unclear.

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de microbiologie et médecine moléculaire

Research groups

Virologie moléculaire (275)

Citation (ISO format)

POURCELOT, Marie et al. The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing. In: BMC biology, 2016, vol. 14, p. 69. doi: 10.1186/s12915-016-0292-z

Article (Published version)

Identifiers

PID : unige:89728
DOI : 10.1186/s12915-016-0292-z
PMID : 27538435

Journal ISSN1741-7007

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The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing

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