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Title

The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing

Authors
Pourcelot, Marie
Zemirli, Naima
Silva Da Costa, Leandro
Loyant, Roxane
Vitour, Damien
Munitic, Ivana
Vazquez, Aimé
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Published in BMC Biology. 2016, vol. 14, p. 69
Abstract After viral infection and the stimulation of some pattern-recognition receptors, TANK-binding kinase I (TBK1) is activated by K63-linked polyubiquitination followed by trans-autophosphorylation. While the activated TBK1 induces type I interferon production by phosphorylating the transcription factor IRF3, the precise molecular mechanisms underlying TBK1 activation remain unclear.
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PMID: 27538435
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Article (Published version) (3.4 MB) - public document Free access
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Research group Virologie moléculaire (275)
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POURCELOT, Marie et al. The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing. In: BMC Biology, 2016, vol. 14, p. 69. https://archive-ouverte.unige.ch/unige:89728

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Deposited on : 2016-12-02

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