UNIGE document Scientific Article
previous document  unige:897  next document
add to browser collection

Matching the diameter of ePTFE bypass prosthesis with a native artery improves neoendothelialization

Cikirikcioglu, Y. B.
Osorio-da Cruz, S.
Published in European Surgical Research. 2008, vol. 40, no. 4, p. 333-340
Abstract BACKGROUND AND AIM: The undersizing of the bypass graft diameter compared to native artery changes blood flow characteristics and velocity which may affect conduit neo-endothelialization, intimal hyperplasia reaction and patency. The aim of this study was to evaluate conduit neoendothelialization, intimal hyperplasia reaction and patency results between undersized and matched ePTFE grafts. MATERIAL AND METHODS: In 16 male Sprague-Dawley rats, undersized (1-mm internal diameter) and matched (2-mm internal diameter) ePTFE grafts were anastomosed end-to-end in the infrarenal abdominal aorta. Blood flow volume per minute was measured and wall shear stress was calculated for each group. After 3 weeks of follow-up, angiography was performed via the left carotid artery just before sacrifice. Conduit neoendothelialization and intimal hyperplasia reaction were measured by computer-assisted morphometry. RESULTS: Wall shear stress was 8 times higher for the undersized group (840.56 vs. 105.07 mPa). Three weeks after implantation, conduit neoendothelialization was better in matched grafts compared to undersized grafts (441 vs. 574 microm, p = 0.008). Intimal hyperplasia reaction was similar for both groups (8.7 vs. 6.7 microm(2)/microm for undersized and matched grafts, respectively). Patency rate was 7/8 for undersized and 8/8 for matched ePTFE grafts. CONCLUSION: Although the graft patency and the intimal hyperplasia reaction were not different between the two groups after 3 weeks, matched grafts had a significantly better endothelialization compared to undersized grafts. This short-term beneficial effect may influence long-term patency results.
Keywords AnimalsAorta, Abdominal/pathology/physiology/surgeryAortographyArterial Occlusive Diseases/surgeryBiomechanicsBlood Vessel ProsthesisEndothelium, Vascular/pathology/physiologyMalePolytetrafluoroethyleneRatsRats, Sprague-DawleyRegeneration/physiologyTunica Intima/physiologyVascular Patency/physiology
PMID: 18303269
Full text
Research group Chirurgie cardio-vasculaire (105)
(ISO format)
CIKIRIKCIOGLU, Mustafa et al. Matching the diameter of ePTFE bypass prosthesis with a native artery improves neoendothelialization. In: European Surgical Research, 2008, vol. 40, n° 4, p. 333-340. doi: 10.1159/000118029 https://archive-ouverte.unige.ch/unige:897

501 hits

0 download


Deposited on : 2009-02-23

Export document
Format :
Citation style :