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Title

Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney injury requiring continuous renal replacement therapy: a randomized controlled trial

Authors
Tataw, James
Published in Critical Care. 2015, vol. 19, p. 91
Abstract A systemic anticoagulation is often required to prevent circuit and filter clotting in ICU patients undergoing continuous renal replacement therapy (CRRT). A regional citrate-based anticoagulation (RCA) does not induce a systemic anticoagulation and prolongs the filter lifespan, but metabolic side-effects have been associated with this therapy. We conducted a randomized controlled trial with patients requiring CRRT to determine whether RCA using a balanced predilution replacement fluid is more effective than heparin in terms of renal replacement delivered dose and safety profile.
Keywords Acute Kidney Injury/drug therapyAgedAnticoagulants/therapeutic useBlood CoagulationCitrates/therapeutic useFemaleFiltrationHeparin/therapeutic useHumansIntensive Care UnitsMaleMiddle AgedRenal Replacement Therapy/methodsSurvival Rate
Identifiers
PMID: 25881975
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Article (Published version) (443 Kb) - public document Free access
Structures
Research group Groupe Pierre-Yves Martin (néphrologie) (30)
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(ISO format)
STUCKER, Fabien Jérôme et al. Efficacy and safety of citrate-based anticoagulation compared to heparin in patients with acute kidney injury requiring continuous renal replacement therapy: a randomized controlled trial. In: Critical Care, 2015, vol. 19, p. 91. https://archive-ouverte.unige.ch/unige:89624

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Deposited on : 2016-11-30

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