UNIGE document Scientific Article
previous document  unige:89621  next document
add to browser collection
Title

The role of rituximab in the treatment of ANCA-associated vasculitides (AAV)

Authors
Daikeler, Thomas
Kistler, Andreas D
Vogt, Bruno
Huynh-Do, Uyen
Published in Schweizerische medizinische Wochenschrift. 2015, vol. 145, w14103
Abstract The antineutrophil cytoplasmic antibody (ANCA) associated vasculitides (AAV) are a group of primary vasculitides that affect predominantly small- to medium-sized blood vessels. AAV include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA). Disease severity is dictated by the location and extent of the blood vessels affected. If left untreated, systemic forms of AAV are often fatal. The advent of immunosuppressive therapy (cyclophosphamide plus glucocorticoids) has revolutionised the prognosis for patients with AAV, transforming the course of the disease from fatal to one that can be managed, though not without significant treatment-related toxicity. Recently, the monoclonal antibody rituximab was approved for the treatment of GPA and MPA, providing the first major alternative to cyclophosphamide for induction therapy of AAV. This review explores the emerging role of rituximab in the management of this complex disorder.
Keywords Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapyAntibodies, Monoclonal, Murine-Derived/therapeutic useHumansImmunosuppressive Agents/therapeutic useRemission Induction/methodsRituximab
Identifiers
PMID: 25658140
Full text
Article (Published version) (461 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Groupe Pierre-Yves Martin (néphrologie) (30)
Citation
(ISO format)
DAIKELER, Thomas et al. The role of rituximab in the treatment of ANCA-associated vasculitides (AAV). In: Schweizerische medizinische Wochenschrift, 2015, vol. 145, p. w14103. doi: 10.4414/smw.2015.14103 https://archive-ouverte.unige.ch/unige:89621

346 hits

0 download

Update

Deposited on : 2016-11-30

Export document
Format :
Citation style :