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Genome sequence of Aedes aegypti, a major arbovirus vector

Nene, Vishvanath
CollaborationWith : Zdobnov, Evgeny / Wyder, Stefan
Published in Science. 2007, vol. 316, no. 5832, p. 1718-1723
Abstract We present a draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genome of the malaria vector Anopheles gambiae. Nearly 50% of the Ae. aegypti genome consists of transposable elements. These contribute to a factor of approximately 4 to 6 increase in average gene length and in sizes of intergenic regions relative to An. gambiae and Drosophila melanogaster. Nonetheless, chromosomal synteny is generally maintained among all three insects, although conservation of orthologous gene order is higher (by a factor of approximately 2) between the mosquito species than between either of them and the fruit fly. An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species.
Keywords Aedes/ genetics/metabolismAnimalsAnopheles gambiae/genetics/metabolismArbovirusesBase SequenceDNA Transposable ElementsDengue/prevention & control/transmissionDrosophila melanogaster/geneticsFemaleGenes, InsectGenome, InsectHumansInsect Proteins/geneticsInsect Vectors/ genetics/metabolismMaleMembrane Transport Proteins/geneticsMolecular Sequence DataMultigene FamilyProtein Structure, Tertiary/geneticsSequence Analysis, DNASex CharacteristicsSex Determination (Genetics)Species SpecificitySyntenyTranscription, GeneticYellow Fever/prevention & control/transmission
PMID: 17510324
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Other version: http://www.sciencemag.org/cgi/reprint/316/5832/1718.pdf
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NENE, Vishvanath. Genome sequence of Aedes aegypti, a major arbovirus vector. In: Science, 2007, vol. 316, n° 5832, p. 1718-1723. doi: 10.1126/science.1138878 https://archive-ouverte.unige.ch/unige:8939

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Deposited on : 2010-07-12

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