en
Scientific article
English

Transplantation of iris pigment epithelium into the choroid slows down the degeneration of photoreceptors in the RCS rat

Published inGraefe's archive for clinical and experimental ophthalmology, vol. 238, no. 12, p. 979-984
Publication date2000
Abstract

Trophic factors [e.g. basic fibroblast growth factor (bFGF)] released by transplanted retinal pigment epithelial (RPE) cells are able to slow down the hereditary degeneration of the retina in the Royal College of Surgeons rat in sites distant from the site of transplantation where rod outer segment (ROS) phagocytic activity is not reconstituted by the transplants.

Keywords
  • Animals
  • Cell Survival/physiology
  • Cell Transplantation
  • Choroid/surgery
  • Image Processing, Computer-Assisted
  • Iris/cytology
  • Photoreceptor Cells, Vertebrate/pathology/physiology
  • Pigment Epithelium of Eye/transplantation/ultrastructure
  • Rats
  • Rats, Mutant Strains
  • Retinal Degeneration/genetics/pathology/prevention & control
Affiliation Not a UNIGE publication
Citation (ISO format)
SCHRAERMEYER, U et al. Transplantation of iris pigment epithelium into the choroid slows down the degeneration of photoreceptors in the RCS rat. In: Graefe’s archive for clinical and experimental ophthalmology, 2000, vol. 238, n° 12, p. 979–984.
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Article (Published version)
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Identifiers
ISSN of the journal0721-832X
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