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Transplantation of iris pigment epithelium into the choroid slows down the degeneration of photoreceptors in the RCS rat

Publié dansGraefe's archive for clinical and experimental ophthalmology, vol. 238, no. 12, p. 979-984
Date de publication2000
Résumé

Trophic factors [e.g. basic fibroblast growth factor (bFGF)] released by transplanted retinal pigment epithelial (RPE) cells are able to slow down the hereditary degeneration of the retina in the Royal College of Surgeons rat in sites distant from the site of transplantation where rod outer segment (ROS) phagocytic activity is not reconstituted by the transplants.

Mots-clés
  • Animals
  • Cell Survival/physiology
  • Cell Transplantation
  • Choroid/surgery
  • Image Processing, Computer-Assisted
  • Iris/cytology
  • Photoreceptor Cells, Vertebrate/pathology/physiology
  • Pigment Epithelium of Eye/transplantation/ultrastructure
  • Rats
  • Rats, Mutant Strains
  • Retinal Degeneration/genetics/pathology/prevention & control
Structure d'affiliation Pas une publication de l'UNIGE
Citation (format ISO)
SCHRAERMEYER, U et al. Transplantation of iris pigment epithelium into the choroid slows down the degeneration of photoreceptors in the RCS rat. In: Graefe’s archive for clinical and experimental ophthalmology, 2000, vol. 238, n° 12, p. 979–984.
Fichiers principaux (1)
Article (Published version)
accessLevelRestricted
Identifiants
ISSN du journal0721-832X
354vues
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