Scientific Article - Case report
previous document  unige:89331  next document
add to browser collection

Two cases of toxic anterior segment syndrome from generic trypan blue

Buzard, Kurt
Zhang, Jue-Rong
Stripecke, Renata
Sunalp, Murad
Published in Journal of cataract and refractive surgery. 2010, vol. 36, no. 12, p. 2195-2199
Abstract We report 2 cases of toxic anterior segment syndrome (TASS) resulting from impurities in generic trypan blue that was administered intracamerally to improve visualization of the capsule. Histology of the corneal buttons revealed foci of inflammatory response and complete loss of endothelial cells. Cell culture analysis showed that the generic trypan blue was approximately twice as toxic to the endothelium as a proprietary trypan blue. Ophthalmologists should be aware that any substance administered intraocularly can be a source of complications, and they should know the source of all material used in surgery.
Keywords Aorta, Thoracic/cytologyCell SurvivalCells, CulturedColoring Agents/adverse effects/toxicityCorneal Edema/chemically induced/diagnosisDrugs, GenericEndothelium, Corneal/drug effects/pathologyEndothelium, Vascular/drug effects/pathologyEndotoxins/adverse effects/toxicityFemaleHumansLens Capsule, Crystalline/pathologyLens Implantation, IntraocularMaleMiddle AgedPhacoemulsificationTrypan Blue/adverse effects/toxicityUveitis, Anterior/chemically induced/diagnosis
PMID: 21111323
Full text
Article (Published version) (666 Kb) - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
BUZARD, Kurt et al. Two cases of toxic anterior segment syndrome from generic trypan blue. In: Journal of cataract and refractive surgery, 2010, vol. 36, n° 12, p. 2195-2199. doi: 10.1016/j.jcrs.2010.09.017

367 hits

0 download


Deposited on : 2016-11-23

Export document
Format :
Citation style :