Scientific article
Case report

Two cases of toxic anterior segment syndrome from generic trypan blue

Published inJournal of cataract and refractive surgery, vol. 36, no. 12, p. 2195-2199
Publication date2010

We report 2 cases of toxic anterior segment syndrome (TASS) resulting from impurities in generic trypan blue that was administered intracamerally to improve visualization of the capsule. Histology of the corneal buttons revealed foci of inflammatory response and complete loss of endothelial cells. Cell culture analysis showed that the generic trypan blue was approximately twice as toxic to the endothelium as a proprietary trypan blue. Ophthalmologists should be aware that any substance administered intraocularly can be a source of complications, and they should know the source of all material used in surgery.

  • Aorta, Thoracic/cytology
  • Cell Survival
  • Cells, Cultured
  • Coloring Agents/adverse effects/toxicity
  • Corneal Edema/chemically induced/diagnosis
  • Drugs, Generic
  • Endothelium, Corneal/drug effects/pathology
  • Endothelium, Vascular/drug effects/pathology
  • Endotoxins/adverse effects/toxicity
  • Female
  • Humans
  • Lens Capsule, Crystalline/pathology
  • Lens Implantation, Intraocular
  • Male
  • Middle Aged
  • Phacoemulsification
  • Trypan Blue/adverse effects/toxicity
  • Uveitis, Anterior/chemically induced/diagnosis
Affiliation Not a UNIGE publication
Citation (ISO format)
BUZARD, Kurt et al. Two cases of toxic anterior segment syndrome from generic trypan blue. In: Journal of cataract and refractive surgery, 2010, vol. 36, n° 12, p. 2195–2199. doi: 10.1016/j.jcrs.2010.09.017
Main files (1)
Article (Published version)
ISSN of the journal0886-3350

Technical informations

Creation09/21/2016 4:36:00 PM
First validation09/21/2016 4:36:00 PM
Update time03/15/2023 12:59:38 AM
Status update03/15/2023 12:59:37 AM
Last indexation10/19/2023 2:31:18 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack