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Scientific article
English

Effect of photodynamic therapy on the function of the outer blood-retinal barrier in an in vitro model

Published inGraefe's archive for clinical and experimental ophthalmology, vol. 244, no. 8, p. 1015-1021
Publication date2006
Abstract

Photodynamic therapy (PDT) is a well established clinical treatment for age-related macular degeneration (AMD), and comprises intravenous injection of verteporfin and subsequent application of a non-thermal laser beam to the area of AMD to induce selective vascular occlusion. Since there is evidence that PDT may cause outer blood-retinal barrier (BRB) breakdown and possibly RPE cell alteration, we investigated the effect of PDT on the BRB function of the RPE in an in vitro model.

Keywords
  • Blood-Retinal Barrier/physiology
  • Capillary Permeability/drug effects
  • Cell Survival
  • Cells, Cultured
  • Electric Impedance
  • Fluorescein/metabolism
  • Humans
  • Intercellular Junctions/physiology
  • Photochemotherapy
  • Photosensitizing Agents/pharmacology
  • Pigment Epithelium of Eye/drug effects/physiology/ultrastructure
  • Porphyrins/pharmacology
Affiliation Not a UNIGE publication
Citation (ISO format)
MENNEL, Stefan et al. Effect of photodynamic therapy on the function of the outer blood-retinal barrier in an in vitro model. In: Graefe’s archive for clinical and experimental ophthalmology, 2006, vol. 244, n° 8, p. 1015–1021. doi: 10.1007/s00417-005-0237-7
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0721-832X
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