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Title

Effect of photodynamic therapy on the function of the outer blood-retinal barrier in an in vitro model

Authors
Mennel, Stefan
Peter, Silvia
Meyer, Carsten H
Published in Graefe's Archive for Clinical and Experimental Ophthalmology. 2006, vol. 244, no. 8, p. 1015-1021
Abstract Photodynamic therapy (PDT) is a well established clinical treatment for age-related macular degeneration (AMD), and comprises intravenous injection of verteporfin and subsequent application of a non-thermal laser beam to the area of AMD to induce selective vascular occlusion. Since there is evidence that PDT may cause outer blood-retinal barrier (BRB) breakdown and possibly RPE cell alteration, we investigated the effect of PDT on the BRB function of the RPE in an in vitro model.
Keywords Blood-Retinal Barrier/physiologyCapillary Permeability/drug effectsCell SurvivalCells, CulturedElectric ImpedanceFluorescein/metabolismHumansIntercellular Junctions/physiologyPhotochemotherapyPhotosensitizing Agents/pharmacologyPigment Epithelium of Eye/drug effects/physiology/ultrastructurePorphyrins/pharmacology
Identifiers
PMID: 16421742
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MENNEL, Stefan et al. Effect of photodynamic therapy on the function of the outer blood-retinal barrier in an in vitro model. In: Graefe's Archive for Clinical and Experimental Ophthalmology, 2006, vol. 244, n° 8, p. 1015-1021. https://archive-ouverte.unige.ch/unige:89322

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Deposited on : 2016-11-23

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