Scientific article

Effects of bevacizumab (Avastin) on retinal cells in organotypic culture

Published inInvestigative ophthalmology & visual science, vol. 49, no. 7, p. 3164-3171
Publication date2008

Repetitive intravitreal injections of bevacizumab are a successful treatment option for exudative age-related macular degeneration (AMD). The aim of this study was to evaluate the toxicity of bevacizumab in the adult mammalian neurosensory retina in culture.

  • Actins/metabolism
  • Angiogenesis Inhibitors/administration & dosage/toxicity
  • Animals
  • Antibodies, Monoclonal/administration & dosage/toxicity
  • Antibodies, Monoclonal, Humanized
  • Bevacizumab
  • Dose-Response Relationship, Drug
  • Glial Fibrillary Acidic Protein/metabolism
  • Muscle, Smooth, Vascular/metabolism
  • Organ Culture Techniques
  • Photoreceptor Cells, Vertebrate/drug effects
  • Retina/cytology/drug effects/metabolism
  • Retinal Ganglion Cells/drug effects
  • Retinal Vessels/metabolism
  • Swine
  • Tissue Distribution
  • Vimentin/metabolism
Affiliation Not a UNIGE publication
Citation (ISO format)
KAEMPF, Stefanie et al. Effects of bevacizumab (Avastin) on retinal cells in organotypic culture. In: Investigative ophthalmology & visual science, 2008, vol. 49, n° 7, p. 3164–3171. doi: 10.1167/iovs.07-1265
Main files (1)
Article (Published version)
ISSN of the journal0146-0404

Technical informations

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