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Effects of bevacizumab (Avastin) on retinal cells in organotypic culture

Kaempf, Stefanie
Johnen, Sandra
Salz, Anna Katharina
Weinberger, Andreas
Walter, Peter
Published in Investigative ophthalmology & visual science. 2008, vol. 49, no. 7, p. 3164-3171
Abstract Repetitive intravitreal injections of bevacizumab are a successful treatment option for exudative age-related macular degeneration (AMD). The aim of this study was to evaluate the toxicity of bevacizumab in the adult mammalian neurosensory retina in culture.
Keywords Actins/metabolismAngiogenesis Inhibitors/administration & dosage/toxicityAnimalsAntibodies, Monoclonal/administration & dosage/toxicityAntibodies, Monoclonal, HumanizedBevacizumabDose-Response Relationship, DrugGlial Fibrillary Acidic Protein/metabolismMuscle, Smooth, Vascular/metabolismOrgan Culture TechniquesPhotoreceptor Cells, Vertebrate/drug effectsRetina/cytology/drug effects/metabolismRetinal Ganglion Cells/drug effectsRetinal Vessels/metabolismSwineTissue DistributionVimentin/metabolism
PMID: 18344448
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KAEMPF, Stefanie et al. Effects of bevacizumab (Avastin) on retinal cells in organotypic culture. In: Investigative ophthalmology & visual science, 2008, vol. 49, n° 7, p. 3164-3171. doi: 10.1167/iovs.07-1265

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Deposited on : 2016-11-23

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