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Title

Immunodeficiency and the risk of cervical intraepithelial neoplasia 2/3 and cervical cancer: A nested case-control study in the Swiss HIV cohort study

Authors
Clifford, Gary M
Franceschi, Silvia
Keiser, Olivia
Schöni-Affolter, Franziska
Lise, Mauro
Dehler, Silvia
Levi, Fabio
Mousavi, Mohsen
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Published in International Journal of Cancer. 2016, vol. 138, no. 7, p. 1732-1740
Abstract HIV-infected women are at increased risk of cervical intraepithelial neoplasia (CIN) and invasive cervical cancer (ICC), but it has been difficult to disentangle the influences of heavy exposure to HPV infection, inadequate screening and immunodeficiency. A case-control study including 364 CIN2/3 and 20 ICC cases matched to 1,147 controls was nested in the Swiss HIV Cohort Study (1985-2013). CIN2/3 risk was significantly associated with low CD4+ cell counts, whether measured as nadir [odds ratio (OR) per 100-cell/μL decrease = 1.15, 95% CI: 1.08, 1.22], or at CIN2/3 diagnosis (1.10, 95% CI: 1.04, 1.16). An association was evident even for nadir CD4+ 200-349 versus ≥350 cells/μL (OR = 1.57, 95% CI: 1.09, 2.25). After adjustment for nadir CD4+, a protective effect of >2-year cART use was seen against CIN2/3 (OR versus never cART use = 0.64, 95% CI: 0.42, 0.98). Despite low study power, similar associations were seen for ICC, notably with nadir CD4+ (OR for 50 vs. >350 cells/μL= 11.10, 95% CI: 1.24, 100). HPV16-L1 antibodies were significantly associated with CIN2/3, but HPV16-E6 antibodies were nearly exclusively detected in ICC. In conclusion, worsening immunodeficiency, even at only moderately decreased CD4+ cell counts, is a significant risk factor for CIN2/3 and cervical cancer.
Keywords AdultAnti-HIV Agents/therapeutic useCase-Control StudiesCervical Intraepithelial Neoplasia/epidemiology/immunologyCohort StudiesFemaleHIV Infections/complications/drug therapy/immunologyHumansImmunocompromised Host/immunologyIncidenceOdds RatioSwitzerlandUterine Cervical Neoplasms/epidemiology/immunology
Identifiers
PMID: 26537763
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Article (Published version) (244 Kb) - public document Free access
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Research group Groupe Bouchardy Magnin Christine (Registre genevois des tumeurs) (532)
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CLIFFORD, Gary M et al. Immunodeficiency and the risk of cervical intraepithelial neoplasia 2/3 and cervical cancer: A nested case-control study in the Swiss HIV cohort study. In: International Journal of Cancer, 2016, vol. 138, n° 7, p. 1732-1740. https://archive-ouverte.unige.ch/unige:89121

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Deposited on : 2016-11-18

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