en
Scientific article
Open access
English

Value of brain natriuretic peptide in the perioperative follow-up of children with valvular disease

Published inIntensive care medicine, vol. 34, no. 6, p. 1109-1113
Collection
  • Open Access - Licence nationale Springer
Publication date2008
Abstract

OBJECTIVE: To characterize N-terminal pro-brain natriuretic peptide (N-proBNP) and troponin I (TnI) profile following mitral and/or aortic valve surgery and to evaluate correlations with echocardiography measures and outcome criteria. DESIGN AND SETTING: Prospective cross-controlled study in a university children's hospital. PATIENTS: Twenty children with acquired valvular disease requiring valvular surgery. INTERVENTIONS: We prospectively studied clinical, biochemical, and echocardiographic characteristics at baseline and 6, 12, 24 h and 3-4 weeks postoperatively. RESULTS: TnI peaked 6 h after surgery and remained elevated during the first 24 h. N-proBNP was significantly lower 3-4 weeks after surgery than during the perioperative period. Overall, N-proBNP was correlated with the Pediatric Heart Failure Index, left ventricle shortening fraction, left atrium to aorta ratio, left ventricle mass index, end-systolic wall stress, and with outcome measures such as inotropic score, duration of inotropic support, and ICU length of stay. Preoperative N-proBNP was significantly more elevated in patients with complicated outcome than in patients with uneventful postoperative course. CONCLUSIONS: In pediatric valvular patients, perioperative N-proBNP is a promising risk stratification predicting factor. It is correlated with evolutive echocardiographic measures, need for inotropic support, and ICU length of stay.

Keywords
  • Biological Markers/blood
  • Child
  • Echocardiography
  • Heart Valve Diseases/blood/surgery/ultrasonography
  • Humans
  • Natriuretic Peptide, Brain/blood
  • Prospective Studies
  • ROC Curve
  • Statistics, Nonparametric
  • Treatment Outcome
  • Troponin/blood
Citation (ISO format)
TISSIÈRES, Pierre et al. Value of brain natriuretic peptide in the perioperative follow-up of children with valvular disease. In: Intensive care medicine, 2008, vol. 34, n° 6, p. 1109–1113. doi: 10.1007/s00134-008-1025-8
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Article (Published version)
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Identifiers
ISSN of the journal0342-4642
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197downloads

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