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Value of brain natriuretic peptide in the perioperative follow-up of children with valvular disease |
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Published in | Intensive care medicine. 2008, vol. 34, no. 6, p. 1109-13 | |
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Open Access - Licence nationale Springer |
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Abstract | OBJECTIVE: To characterize N-terminal pro-brain natriuretic peptide (N-proBNP) and troponin I (TnI) profile following mitral and/or aortic valve surgery and to evaluate correlations with echocardiography measures and outcome criteria. DESIGN AND SETTING: Prospective cross-controlled study in a university children's hospital. PATIENTS: Twenty children with acquired valvular disease requiring valvular surgery. INTERVENTIONS: We prospectively studied clinical, biochemical, and echocardiographic characteristics at baseline and 6, 12, 24 h and 3-4 weeks postoperatively. RESULTS: TnI peaked 6 h after surgery and remained elevated during the first 24 h. N-proBNP was significantly lower 3-4 weeks after surgery than during the perioperative period. Overall, N-proBNP was correlated with the Pediatric Heart Failure Index, left ventricle shortening fraction, left atrium to aorta ratio, left ventricle mass index, end-systolic wall stress, and with outcome measures such as inotropic score, duration of inotropic support, and ICU length of stay. Preoperative N-proBNP was significantly more elevated in patients with complicated outcome than in patients with uneventful postoperative course. CONCLUSIONS: In pediatric valvular patients, perioperative N-proBNP is a promising risk stratification predicting factor. It is correlated with evolutive echocardiographic measures, need for inotropic support, and ICU length of stay. | |
Keywords | Biological Markers/blood — Child — Echocardiography — Heart Valve Diseases/blood/surgery/ultrasonography — Humans — Natriuretic Peptide, Brain/blood — Prospective Studies — ROC Curve — Statistics, Nonparametric — Treatment Outcome — Troponin/blood | |
Identifiers | PMID: 18283430 | |
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![]() ![]() Other version: http://www.springerlink.com/content/hh0t3n22206ng624/fulltext.html |
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Structures | ||
Research groups | Chirurgie cardio-vasculaire (105) Enfants et hyperréactivité bronchique (69) Groupe Pugin Jérôme (Soins intensifs) (587) L'hypertension pulmonaire (pédiatrie) (228) | |
Citation (ISO format) | TISSIÈRES, Pierre et al. Value of brain natriuretic peptide in the perioperative follow-up of children with valvular disease. In: Intensive care medicine, 2008, vol. 34, n° 6, p. 1109-13. doi: 10.1007/s00134-008-1025-8 https://archive-ouverte.unige.ch/unige:891 |