Fibroblast growth factor-23 and cardiovascular disease in the general population: the Multi-Ethnic Study of Atherosclerosis

Kestenbaum, Bryan; Sachs, Michael C; Hoofnagle, Andy N; Siscovick, David S; Ix, Joachim H; Robinson-Cohen, Cassianne; Lima, Joao A C; Polak, Joseph F; Blondon, Marc; Ruzinski, John; Rock, Denise; de Boer, Ian H

doi:10.1161/CIRCHEARTFAILURE.113.000952

Scientific article

English

Fibroblast growth factor-23 and cardiovascular disease in the general population: the Multi-Ethnic Study of Atherosclerosis

ContributorsKestenbaum, Bryan; Sachs, Michael C; Hoofnagle, Andy N; Siscovick, David S; Ix, Joachim H; Robinson-Cohen, Cassianne; Lima, Joao A C; Polak, Joseph F; Blondon, Marc

; Ruzinski, John; Rock, Denise; de Boer, Ian H

Published inCirculation. Heart failure, vol. 7, no. 3, p. 409-417

Publication date2014

Abstract

Fibroblast growth factor-23 (FGF-23) is a phosphate regulatory hormone that directly stimulates left ventricular hypertrophy in experimental models. The role of FGF-23 in cardiovascular disease development in the general population is unclear. We tested associations of FGF-23 with major subclinical and clinical cardiovascular disease outcomes in a large prospective cohort.

Keywords

Aged
Aged, 80 and over
Atherosclerosis/blood/epidemiology/ethnology
Biomarkers/blood
Calcium/metabolism
Cardiovascular Diseases/blood/epidemiology/ethnology
Carotid Intima-Media Thickness
Cohort Studies
Coronary Vessels/metabolism
Female
Fibroblast Growth Factors/blood
Heart Ventricles/pathology
Humans
Incidence
Magnetic Resonance Imaging
Male
Middle Aged
Prospective Studies
Risk Factors
United States

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

La maladie thromboembolique veineuse (808)

Citation (ISO format)

KESTENBAUM, Bryan et al. Fibroblast growth factor-23 and cardiovascular disease in the general population: the Multi-Ethnic Study of Atherosclerosis. In: Circulation. Heart failure, 2014, vol. 7, n° 3, p. 409–417. doi: 10.1161/CIRCHEARTFAILURE.113.000952

Article (Published version)

Identifiers

PID : unige:89074
DOI : 10.1161/CIRCHEARTFAILURE.113.000952
PMID : 24668259

Journal ISSN1941-3289

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Fibroblast growth factor-23 and cardiovascular disease in the general population: the Multi-Ethnic Study of Atherosclerosis

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