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Title

Sélection d'un médicament dans une classe thérapeutique donnée : l'exemple des «inhibiteurs de l'HMG-CoA réductase»

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Published in Revue médicale suisse. 2005, vol. 1, no. 14, p. 949-953
Abstract The HMG-CoA reductase inhibitors have similar therapeutic targets and indications. However, their potential pharmacokinetic drug-drug interaction profile may play a significant role in their safety profile in polymedicated and polymorbid patients and can serve as a selection criterion. If their utility is clearly demonstrated in selected conditions, their safety profile remains of concern. Beside dose-related hepatic and muscular injury, other rare and important adverse drug reactions have been reported after prolonged administration such as polyneuropathy, fibrotic interstitial pulmonary disease and lupus-like syndrome. Teratogenicity has also been associated with statin therapy.
Keywords HumansHydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects/therapeutic use
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PMID: 15898679
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Research group Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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GIRARDIN, François, DESMEULES, Jules Alexandre, DAYER, Pierre. Sélection d'un médicament dans une classe thérapeutique donnée : l'exemple des «inhibiteurs de l'HMG-CoA réductase». In: Revue médicale suisse, 2005, vol. 1, n° 14, p. 949-953. https://archive-ouverte.unige.ch/unige:89018

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Deposited on : 2016-11-16

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