UNIGE document Scientific Article
previous document  unige:8901  next document
add to browser collection
Title

Inherited dysfibrinogenemia: clinical phenotypes associated with five different fibrinogen structure defects
Authors
Miesbach, Wolfgang
Scharrer, Inge
Henschen, Agnes
Neerman Arbez, Marguerite
Spitzer, Silvia
Galanakis, Dennis
Published in Blood Coagulation and Fibrinolysis. 2010, vol. 21, no. 1, p. 35-40
Abstract Hereditary dysfibrinogenemia is a rare clotting disorder, which results from mutations in at least one of the three fibrinogen genes. We examined the frequency of hemostatic clinical and laboratory anomalies at presentation of 37 probands from 12 unrelated families with five different defects (Aalpha R16C, gamma A357T, gamma318-319 del, gamma M310T, and Aalpha R16S), among. The median age was 51 years (11-86 years). Among 62% who were women three (13%) had experienced one or more spontaneous abortion. More than half of the probands had experienced one or more undue bleeding episode, easy bruising being by far the most common. In 19% of probands (9/37, all above age of 50 years), had experienced at least one episode of arterial or venous thrombosis. Among these, were two (7%) with deep venous thrombosis, seven with arterial thrombosis, and five (14%) had experienced both. We propose that the higher frequency of prolonged PT than aPTT, in ours and in other reported studies, reflects the polymerization delay, which in aPTT is attenuated owing to contact activation prior to calcium addition.
Keywords Abortion, Spontaneous/blood/etiology — Adolescent — Adult — Afibrinogenemia/ complications/epidemiology/genetics — Aged — Aged, 80 and over — Amino Acid Substitution — Arterial Occlusive Diseases/blood/etiology — Blood Coagulation Tests — Child — DNA Mutational Analysis — Female — Fibrinogen/analysis/ genetics — Hemorrhage/blood/ etiology — Humans — Male — Middle Aged — Mutation, Missense — Point Mutation — Postpartum Hemorrhage/etiology — Pregnancy — Pregnancy Complications, Hematologic/blood/etiology — Protein Structure, Quaternary — Protein Subunits — Purpura/blood/ etiology — Sequence Deletion — Structure-Activity Relationship — Thrombosis/blood/ etiology — Young Adult
Identifiers
PMID: 19923982
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=N&PAGE=fulltext&AN=00001721-201001000-00007&LSLINK=80&D=ovft
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Citation
(ISO format) 		MIESBACH, Wolfgang et al. Inherited dysfibrinogenemia: clinical phenotypes associated with five different fibrinogen structure defects. In: Blood Coagulation and Fibrinolysis, 2010, vol. 21, n° 1, p. 35-40. https://archive-ouverte.unige.ch/unige:8901

295 hits

0 download

Contact an author

Update request

Update

Deposited on : 2010-07-12

Export document
Format :
Citation style :