en
Scientific article
English

Role of chromatin, environmental changes and single cell heterogeneity in non-coding transcription and gene regulation

Published inCurrent opinion in cell biology, vol. 34, p. 16-22
Publication date2015
Abstract

The number and variety of factors underlying control of gene expression have been frequently underestimated. Non-coding RNAs generated through pervasive transcription have recently been implicated in shaping the transcriptional landscape in different organisms from bacteria to higher eukaryotes, adding a previously unexpected layer of complexity to the process of gene regulation. In this review, we highlight non-coding transcription-dependent regulatory mechanisms linked to chromatin organization and environmental changes, and particular emphasis is given to single-cell approaches, which have been crucial in dissecting cell-to-cell variability. These studies have revealed that non-coding transcription can underlie the extensive heterogeneity in patterns of gene expression within a cell population.

Research group
Citation (ISO format)
CASTELNUOVO, Manuele, STUTZ, Françoise. Role of chromatin, environmental changes and single cell heterogeneity in non-coding transcription and gene regulation. In: Current opinion in cell biology, 2015, vol. 34, p. 16–22. doi: 10.1016/j.ceb.2015.04.011
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0955-0674
466views
0downloads

Technical informations

Creation11/11/2016 5:30:00 PM
First validation11/11/2016 5:30:00 PM
Update time03/15/2023 12:55:28 AM
Status update03/15/2023 12:55:28 AM
Last indexation01/16/2024 10:14:45 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack