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Role of chromatin, environmental changes and single cell heterogeneity in non-coding transcription and gene regulation

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Published in Current Opinion in Cell Biology. 2015, vol. 34, p. 16-22
Abstract The number and variety of factors underlying control of gene expression have been frequently underestimated. Non-coding RNAs generated through pervasive transcription have recently been implicated in shaping the transcriptional landscape in different organisms from bacteria to higher eukaryotes, adding a previously unexpected layer of complexity to the process of gene regulation. In this review, we highlight non-coding transcription-dependent regulatory mechanisms linked to chromatin organization and environmental changes, and particular emphasis is given to single-cell approaches, which have been crucial in dissecting cell-to-cell variability. These studies have revealed that non-coding transcription can underlie the extensive heterogeneity in patterns of gene expression within a cell population.
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Research group Groupe Stutz
Project FNS: 31003A_130292
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CASTELNUOVO, Manuele, STUTZ, Françoise. Role of chromatin, environmental changes and single cell heterogeneity in non-coding transcription and gene regulation. In: Current Opinion in Cell Biology, 2015, vol. 34, p. 16-22. https://archive-ouverte.unige.ch/unige:88894

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Deposited on : 2016-11-14

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