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Interaction between vitamin B6 metabolism, nitrogen metabolism and autoimmunity

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Published in Plant Signaling and Behavior. 2016, vol. 11, no. 4, p. e1161876
Abstract The essential micronutrient vitamin B6 is best known in its enzymatic cofactor form, pyridoxal 5'-phosphate (PLP). However, vitamin B6 comprises the amine pyridoxamine 5'-phosphate (PMP) and the alcohol pyridoxine 5'-phosphate (PNP) in addition to PLP, as well as their corresponding non-phosphorylated forms. The different B6 forms (called vitamers) are enzymatically interconverted in a ubiquitous salvage pathway. Recently, we have shown that balancing the ratio of the different B6 vitamers in particular PMP by the PMP/PNP oxidase PDX3 is essential for growth and development in Arabidopsis thaliana. Intriguingly, nitrate to ammonium conversion is impaired in pdx3 mutants, such that the mutants become ammonium-dependent, suggesting an interaction between vitamin B6 and nitrogen metabolism. In addition, we found a strong up-regulation of genes related to plant defense. Here, we further show that pdx3 mutants display a temperature-sensitive phenotype that is typical of autoimmune mutants and is possibly connected to the impaired nitrogen metabolism.
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PMID: 27018849
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Article (Published version) (1 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Projects FNS: 31003A-141117/1
EMBO ASTF 485-2014
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COLINAS MARTINEZ, Maite Felicitas, FITZPATRICK, Thérésa Bridget. Interaction between vitamin B6 metabolism, nitrogen metabolism and autoimmunity. In: Plant Signaling and Behavior, 2016, vol. 11, n° 4, p. e1161876. https://archive-ouverte.unige.ch/unige:88857

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Deposited on : 2016-11-14

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