UNIGE document Scientific Article
previous document  unige:88857  next document
add to browser collection

Interaction between vitamin B6 metabolism, nitrogen metabolism and autoimmunity

Published in Plant Signaling and Behavior. 2016, vol. 11, no. 4, p. e1161876
Abstract The essential micronutrient vitamin B6 is best known in its enzymatic cofactor form, pyridoxal 5'-phosphate (PLP). However, vitamin B6 comprises the amine pyridoxamine 5'-phosphate (PMP) and the alcohol pyridoxine 5'-phosphate (PNP) in addition to PLP, as well as their corresponding non-phosphorylated forms. The different B6 forms (called vitamers) are enzymatically interconverted in a ubiquitous salvage pathway. Recently, we have shown that balancing the ratio of the different B6 vitamers in particular PMP by the PMP/PNP oxidase PDX3 is essential for growth and development in Arabidopsis thaliana. Intriguingly, nitrate to ammonium conversion is impaired in pdx3 mutants, such that the mutants become ammonium-dependent, suggesting an interaction between vitamin B6 and nitrogen metabolism. In addition, we found a strong up-regulation of genes related to plant defense. Here, we further show that pdx3 mutants display a temperature-sensitive phenotype that is typical of autoimmune mutants and is possibly connected to the impaired nitrogen metabolism.
PMID: 27018849
Full text
Article (Published version) (1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Projects FNS: 31003A-141117/1
EMBO ASTF 485-2014
(ISO format)
COLINAS MARTINEZ, Maite Felicitas, FITZPATRICK, Thérésa Bridget. Interaction between vitamin B6 metabolism, nitrogen metabolism and autoimmunity. In: Plant Signaling and Behavior, 2016, vol. 11, n° 4, p. e1161876. doi: 10.1080/15592324.2016.1161876 https://archive-ouverte.unige.ch/unige:88857

304 hits

0 download


Deposited on : 2016-11-14

Export document
Format :
Citation style :