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Scientific article
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Interaction between vitamin B6 metabolism, nitrogen metabolism and autoimmunity

Published inPlant signalling & behavior, vol. 11, no. 4, e1161876
Publication date2016
Abstract

The essential micronutrient vitamin B6 is best known in its enzymatic cofactor form, pyridoxal 5'-phosphate (PLP). However, vitamin B6 comprises the amine pyridoxamine 5'-phosphate (PMP) and the alcohol pyridoxine 5'-phosphate (PNP) in addition to PLP, as well as their corresponding non-phosphorylated forms. The different B6 forms (called vitamers) are enzymatically interconverted in a ubiquitous salvage pathway. Recently, we have shown that balancing the ratio of the different B6 vitamers in particular PMP by the PMP/PNP oxidase PDX3 is essential for growth and development in Arabidopsis thaliana. Intriguingly, nitrate to ammonium conversion is impaired in pdx3 mutants, such that the mutants become ammonium-dependent, suggesting an interaction between vitamin B6 and nitrogen metabolism. In addition, we found a strong up-regulation of genes related to plant defense. Here, we further show that pdx3 mutants display a temperature-sensitive phenotype that is typical of autoimmune mutants and is possibly connected to the impaired nitrogen metabolism.

Citation (ISO format)
COLINAS MARTINEZ, Maite Felicitas, FITZPATRICK, Thérésa Bridget. Interaction between vitamin B6 metabolism, nitrogen metabolism and autoimmunity. In: Plant signalling & behavior, 2016, vol. 11, n° 4, p. e1161876. doi: 10.1080/15592324.2016.1161876
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ISSN of the journal1559-2316
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