en
Scientific article
English

Chemoselective Dimerization of Phosphates

Published inOrganic letters, vol. 18, no. 13, p. 3222-3225
Publication date2016
Abstract

A methodology for the synthesis of oligophosphate conjugates using phosphordiamidites is described. This strategy facilitates the straightforward preparation of C2-symmetric dinucleoside tri-, penta-, and heptaphosphates. Moreover, unsymmetric compounds such as thiamine adenosine triphosphate and thiamine cytidine triphosphate can be prepared. The material is used to study the inhibitory activity of thiaminylated nucleotides against adenosine diphosphate ribosyltransferases.

Citation (ISO format)
HOFER, Alexandre et al. Chemoselective Dimerization of Phosphates. In: Organic letters, 2016, vol. 18, n° 13, p. 3222–3225. doi: 10.1021/acs.orglett.6b01466
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1523-7052
427views
1downloads

Technical informations

Creation11/03/2016 1:25:00 PM
First validation11/03/2016 1:25:00 PM
Update time03/15/2023 12:54:21 AM
Status update03/15/2023 12:54:20 AM
Last indexation01/16/2024 10:12:04 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack