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Chemoselective Dimerization of Phosphates

Hofer, Alexandre
Marques, Elia
Kieliger, Nicole
Gatter, Sarah-Kirsten N
Jordi, Sara
Ferrari, Elena
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Published in Organic Letters. 2016, vol. 18, no. 13, p. 3222-3225
Abstract A methodology for the synthesis of oligophosphate conjugates using phosphordiamidites is described. This strategy facilitates the straightforward preparation of C2-symmetric dinucleoside tri-, penta-, and heptaphosphates. Moreover, unsymmetric compounds such as thiamine adenosine triphosphate and thiamine cytidine triphosphate can be prepared. The material is used to study the inhibitory activity of thiaminylated nucleotides against adenosine diphosphate ribosyltransferases.
PMID: 27308921
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HOFER, Alexandre et al. Chemoselective Dimerization of Phosphates. In: Organic Letters, 2016, vol. 18, n° 13, p. 3222-3225. doi: 10.1021/acs.orglett.6b01466 https://archive-ouverte.unige.ch/unige:88725

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Deposited on : 2016-11-07

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