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Title

Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21

Authors
Osoegawa, Kazutoyo
ten Hallers, Boudewijn
Humphray, Sean
Zhu, Baoli
Eyras, Eduardo
Castelo, Robert
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Published in Genome Research. 2007, vol. 17, no. 11, p. 1690-1696
Abstract The goals of the human genome project did not include sequencing of the heterochromatic regions. We describe here an initial sequence of 1.1 Mb of the short arm of human chromosome 21 (HSA21p), estimated to be 10% of 21p. This region contains extensive euchromatic-like sequence and includes on average one transcript every 100 kb. These transcripts show multiple inter- and intrachromosomal copies, and extensive copy number and sequence variability. The sequencing of the "heterochromatic" regions of the human genome is likely to reveal many additional functional elements and provide important evolutionary information.
Keywords Chromosomes, Human, Pair 21Contig MappingEuchromatin/ geneticsGenome, HumanHumansIn Situ Hybridization, FluorescencePolymorphism, Genetic
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PMID: 17895424
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Other version: http://genome.cshlp.org/content/17/11/1690.full.pdf
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LYLE, Robert et al. Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21. In: Genome Research, 2007, vol. 17, n° 11, p. 1690-1696. https://archive-ouverte.unige.ch/unige:8871

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Deposited on : 2010-07-12

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