Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21

Lyle, Robert; Prandini, Paola; Osoegawa, Kazutoyo; ten Hallers, Boudewijn; Humphray, Sean; Zhu, Baoli; Eyras, Eduardo; Castelo, Robert; Bird, C. P.; Gagos, Sarantos; Scott, Carol; Cox, Antony; Deutsch, Samuel; Ucla, Catherine; Cruts, Marc; Dahoun, Sophie; She, Xinwei; Bena, Frédérique; Wang, S. Y.; Van Broeckhoven, Christine; Eichler, E. E.; Guigo, Roderic; Rogers, Jane; de Jong, P. J.; Reymond, Alexandre; Antonarakis, Stylianos

doi:10.1101/gr.6675307

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Title		Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21
Authors		Lyle, Robert Prandini, Paola Osoegawa, Kazutoyo ten Hallers, Boudewijn Humphray, Sean Zhu, Baoli Eyras, Eduardo Castelo, Robert Bird, C. P. Gagos, Sarantos Scott, Carol Cox, Antony Deutsch, Samuel Ucla, Catherine Cruts, Marc Dahoun, Sophie She, Xinwei Bena, Frédérique Wang, S. Y. Van Broeckhoven, Christine Eichler, E. E. Guigo, Roderic Rogers, Jane de Jong, P. J. Reymond, Alexandre Antonarakis, Stylianos show all authors [1 - 26]
Published in		Genome Research. 2007, vol. 17, no. 11, p. 1690-1696
Abstract		The goals of the human genome project did not include sequencing of the heterochromatic regions. We describe here an initial sequence of 1.1 Mb of the short arm of human chromosome 21 (HSA21p), estimated to be 10% of 21p. This region contains extensive euchromatic-like sequence and includes on average one transcript every 100 kb. These transcripts show multiple inter- and intrachromosomal copies, and extensive copy number and sequence variability. The sequencing of the "heterochromatic" regions of the human genome is likely to reveal many additional functional elements and provide important evolutionary information.
Keywords		Chromosomes, Human, Pair 21 — Contig Mapping — Euchromatin/ genetics — Genome, Human — Humans — In Situ Hybridization, Fluorescence — Polymorphism, Genetic
Identifiers		DOI: 10.1101/gr.6675307 PMID: 17895424
Full text		Article - Limited access to UNIGE Other version: http://genome.cshlp.org/content/17/11/1690.full.pdf
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Citation (ISO format)		LYLE, Robert et al. Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21. In: Genome research, 2007, vol. 17, n° 11, p. 1690-1696. doi: 10.1101/gr.6675307 https://archive-ouverte.unige.ch/unige:8871