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Title

Clinical decision rules and D-Dimer in venous thromboembolism: current controversies and future research priorities

Authors
Rodger, Marc A
Le Gal, Gregoire
Wells, Philip
Baglin, Trevor
Aujesky, Drahomir
Palareti, Gualtiero
Huisman, Menno
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Published in Thrombosis Research. 2014, vol. 134, no. 4, p. 763-768
Abstract Venous thromboembolism (VTE) is a potentially lethal clinical condition that is suspected in patients with common clinical complaints, in many and varied, clinical care settings. Once VTE is diagnosed, optimal therapeutic management (thrombolysis, IVC filters, type and duration of anticoagulants) and ideal therapeutic management settings (outpatient, critical care) are also controversial. Clinical prediction tools, including clinical decision rules and D-Dimer, have been developed, and some validated, to assist clinical decision making along the diagnostic and therapeutic management paths for VTE. Despite these developments, practice variation is high and there remain many controversies in the use of the clinical prediction tools. In this narrative review, we highlight challenges and controversies in VTE diagnostic and therapeutic management with a focus on clinical decision rules and D-Dimer.
Keywords Anticoagulants/therapeutic useDecision Support Systems, ClinicalFibrin Fibrinogen Degradation Products/analysisHumansPulmonary Embolism/diagnosis/therapyResearchVenous Thromboembolism/diagnosis/therapy
Identifiers
PMID: 25129416
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Structures
Research group La maladie thromboembolique veineuse (808)
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RODGER, Marc A et al. Clinical decision rules and D-Dimer in venous thromboembolism: current controversies and future research priorities. In: Thrombosis Research, 2014, vol. 134, n° 4, p. 763-768. https://archive-ouverte.unige.ch/unige:88535

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Deposited on : 2016-11-01

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