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Stimulation cérébrale profonde : passé, présent et avenir

Published in Revue médicale suisse. 2015, vol. 11, no. 472, p. 958-961
Abstract Recently awarded by the prestigious Lasker Foundation, high-frequency deep brain stimulation (DBS) has been used for the first time in 1987 in tremor and in 1993 in Parkinson's disease (PD) by the Grenoble group. So far, over 100 000 patients have been operated on worldwide. In PD, DBS induces an almost complete abatement of tremor, motor fluctuations and dyskinesias along with a reduction in levodopa dose. Although its mechanism of action is not fully understood, DBS would inhibit or modulate the expression of abnormal neuronal networks associated with given symptoms. It is therefore expected that DBS will extend to other severe neurological and psychiatric disorders. Furthermore, technological advances of the procedure are ongoing to optimize final outcomes.
Keywords Deep Brain Stimulation/methods/trendsHumansMental Disorders/therapyNervous System Diseases/therapyParkinson Disease/physiopathology/therapy
PMID: 26062220
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Research group Groupe Pierre Burkhard (neurologie) (154)
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POLLAK, Pierre, BURKHARD, Pierre, VINGERHOETS, François. Stimulation cérébrale profonde : passé, présent et avenir. In: Revue médicale suisse, 2015, vol. 11, n° 472, p. 958-961. https://archive-ouverte.unige.ch/unige:88517

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Deposited on : 2016-11-01

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