Scientific article

The myofibroblast in wound healing and fibrosis: answered and unanswered questions

Published inF1000Research, vol. 5
Publication date2016

The discovery of the myofibroblast has allowed definition of the cell responsible for wound contraction and for the development of fibrotic changes. This review summarizes the main features of the myofibroblast and the mechanisms of myofibroblast generation. Myofibroblasts originate from a variety of cells according to the organ and the type of lesion. The mechanisms of myofibroblast contraction, which appear clearly different to those of smooth muscle cell contraction, are described. Finally, we summarize the possible strategies in order to reduce myofibroblast activities and thus influence several pathologies, such as hypertrophic scars and organ fibrosis.

Citation (ISO format)
PIALLAT, Marie-Luce, GABBIANI, Giulio, HINZ, Boris. The myofibroblast in wound healing and fibrosis: answered and unanswered questions. In: F1000Research, 2016, vol. 5. doi: 10.12688/f1000research.8190.1
Main files (1)
Article (Published version)
ISSN of the journal2046-1402

Technical informations

Creation09/02/2016 3:10:00 PM
First validation09/02/2016 3:10:00 PM
Update time03/15/2023 12:52:01 AM
Status update03/15/2023 12:52:01 AM
Last indexation08/30/2023 12:08:54 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack