en
Scientific article
English

Non-IgE-Dependent Hypersensitivity to Rocuronium Reversed by Sugammadex: Report of Three Cases and Hypothesis on the Underlying Mechanism

Published inInternational archives of allergy and immunology, vol. 169, no. 4, p. 256-262
Publication date2016
Abstract

We present 3 cases of pseudoallergic (anaphylactoid) reactions to perioperatively administered rocuronium, which rapidly resolved after sugammadex injection. Allergological workup showed no evidence for immediate-type hypersensitivity to the drugs used for anesthesia, including rocuronium. However, rocuronium induced an irritative reaction in skin tests in all 3 patients and in 3 healthy individuals. This reaction was specifically suppressed by adding sugammadex at a 1:1 molecular proportion to rocuronium before the skin tests. This observation suggests that the patients suffered from a pseudoallergic reaction, and indicates that sugammadex might act via the inhibition of non-IgE mediated MRGPRX2 (Mas-related G-protein-coupled receptor member X2)-triggered mast cell degranulation induced by rocuronium.

Citation (ISO format)
SPOERL, David et al. Non-IgE-Dependent Hypersensitivity to Rocuronium Reversed by Sugammadex: Report of Three Cases and Hypothesis on the Underlying Mechanism. In: International archives of allergy and immunology, 2016, vol. 169, n° 4, p. 256–262. doi: 10.1159/000446182
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1018-2438
411views
1downloads

Technical informations

Creation08/31/2016 11:06:00 AM
First validation08/31/2016 11:06:00 AM
Update time03/15/2023 12:51:56 AM
Status update03/15/2023 12:51:56 AM
Last indexation01/16/2024 10:06:28 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack