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Title

Blocking interferon γ reduces expression of chemokines CXCL9, CXCL10 and CXCL11 and decreases macrophage infiltration in ex vivo cultured arteries from patients with giant cell arteritis

Authors
Corbera-Bellalta, Marc
Planas-Rigol, Ester
Lozano, Ester
Terrades-García, Nekane
Alba, Marco A
Prieto-González, Sergio
García-Martínez, Ana
Albero, Robert
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Published in Annals of the Rheumatic Diseases. 2016, vol. 75, no. 6, p. 1177-1186
Abstract Interferon γ (IFNγ) is considered a seminal cytokine in the pathogenesis of giant cell arteritis (GCA), but its functional role has not been investigated. We explored changes in infiltrating cells and biomarkers elicited by blocking IFNγ with a neutralising monoclonal antibody, A6, in temporal arteries from patients with GCA.
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PMID: 26698852
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Research group Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779)
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CORBERA-BELLALTA, Marc et al. Blocking interferon γ reduces expression of chemokines CXCL9, CXCL10 and CXCL11 and decreases macrophage infiltration in ex vivo cultured arteries from patients with giant cell arteritis. In: Annals of the Rheumatic Diseases, 2016, vol. 75, n° 6, p. 1177-1186. https://archive-ouverte.unige.ch/unige:88479

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Deposited on : 2016-10-28

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