Blocking interferon γ reduces expression of chemokines CXCL9, CXCL10 and CXCL11 and decreases macrophage infiltration in ex vivo cultured arteries from patients with giant cell arteritis

Corbera-Bellalta, Marc; Planas-Rigol, Ester; Lozano, Ester; Terrades-García, Nekane; Alba, Marco A; Prieto-González, Sergio; García-Martínez, Ana; Albero, Robert; Enjuanes, Anna; Espígol-Frigolé, Georgina; Hernández-Rodríguez, José; Roux-Lombard, Pascale; Ferlin, Walter G; Dayer, Jean-Michel; Kosco-Vilbois, Marie H; Cid, Maria C

doi:10.1136/annrheumdis-2015-208371

Scientific article

English

Blocking interferon γ reduces expression of chemokines CXCL9, CXCL10 and CXCL11 and decreases macrophage infiltration in ex vivo cultured arteries from patients with giant cell arteritis

ContributorsCorbera-Bellalta, Marc; Planas-Rigol, Ester; Lozano, Ester; Terrades-García, Nekane; Alba, Marco A; Prieto-González, Sergio; García-Martínez, Ana; Albero, Robert; Enjuanes, Anna; Espígol-Frigolé, Georgina; Hernández-Rodríguez, José; Roux-Lombard, Pascale; Ferlin, Walter G; Dayer, Jean-Michel; Kosco-Vilbois, Marie H; Cid, Maria C

Published inAnnals of the rheumatic diseases, vol. 75, no. 6, p. 1177-1186

Publication date2016

Abstract

Interferon γ (IFNγ) is considered a seminal cytokine in the pathogenesis of giant cell arteritis (GCA), but its functional role has not been investigated. We explored changes in infiltrating cells and biomarkers elicited by blocking IFNγ with a neutralising monoclonal antibody, A6, in temporal arteries from patients with GCA.

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Etude de l'activation des monocytes/macrophages et des polynucléaires neutrophiles (779)

Citation (ISO format)

CORBERA-BELLALTA, Marc et al. Blocking interferon γ reduces expression of chemokines CXCL9, CXCL10 and CXCL11 and decreases macrophage infiltration in ex vivo cultured arteries from patients with giant cell arteritis. In: Annals of the rheumatic diseases, 2016, vol. 75, n° 6, p. 1177–1186. doi: 10.1136/annrheumdis-2015-208371

Article (Published version)

Identifiers

PID : unige:88479
DOI : 10.1136/annrheumdis-2015-208371
PMID : 26698852

Journal ISSN0003-4967

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Creation31/08/2016 13:00:00

First validation31/08/2016 13:00:00

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Blocking interferon γ reduces expression of chemokines CXCL9, CXCL10 and CXCL11 and decreases macrophage infiltration in ex vivo cultured arteries from patients with giant cell arteritis

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