Scientific article

Tissue plasminogen activator in psoriasis

Published inJournal of investigative dermatology, vol. 95, no. 5 Suppl, p. 13S-14S
Publication date1990

Elevated levels of the serine proteinase plasminogen activator are observed in psoriatic lesions. In contrast to normal epidermis, lesional psoriatic epidermis contains primarily tissue type plasminogen activator (tPA) activity and much lower levels of urokinase type plasminogen activator (uPA) activity. Tissue plasminogen activator is also detectable immunocytochemically in lesional psoriatic but not normal epidermis. Similarly, mRNA for tPA is observed in lesional epidermis only. These results suggest that lesional psoriatic epidermis synthesizes enhanced levels of tPA compared to normal. Additional data support the hypothesis that enhanced tPA may be another marker common to psoriatic epidermis, epidermis during wound repair, and keratinocytes in culture. The significance of elevated tPA in psoriatic lesions is presently unclear, but its possible relationship to epidermal proliferation and cutaneous inflammation is under study.

  • Humans
  • Psoriasis/ enzymology
  • RNA, Messenger/analysis
  • Tissue Plasminogen Activator/analysis/ biosynthesis/genetics
Citation (ISO format)
JENSEN, P. J. et al. Tissue plasminogen activator in psoriasis. In: Journal of investigative dermatology, 1990, vol. 95, n° 5 Suppl, p. 13S–14S. doi: 10.1111/1523-1747.ep12505666
Updates (1)
ISSN of the journal0022-202X

Technical informations

Creation07/12/2010 11:58:29 AM
First validation07/12/2010 11:58:29 AM
Update time03/14/2023 3:51:29 PM
Status update03/14/2023 3:51:29 PM
Last indexation10/18/2023 9:54:21 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack