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Title

Increased levels of a chromosome 21-encoded tumour invasion and metastasis factor (TIAM1) mRNA in bone marrow of Down syndrome children during the acute phase of AML(M7)

Authors
Ives, J. H.
Dagna-Bricarelli, F.
Basso, G.
Jee, R.
Cotter, F.
Nizetic, D.
Published in Genes, Chromosomes and Cancer. 1998, vol. 23, no. 1, p. 61-66
Abstract Children with Down syndrome (DS) have a 10-20-fold increased risk of acute lymphocytic leukemia (ALL) and acute myeloid leukemia (AML), compared to non-DS children. The myeloid leukemia that accounts for nearly 50% of DS leukemias is usually the otherwise uncommon megakaryoblastic type (AML-M7). Though an etiological role of trisomy 21 in leukemogenesis has been suggested, the expression of genes on chromosome 21 in relation to trisomy, DS, and specific DS phenotypes such as leukemia is poorly understood. We used a heterologous-mimic competitive RT-PCR technique to measure the mRNA levels of a chromosome 21 tumour invasion and metastasis factor (TIAM1) directly in bone marrow samples of DS leukemic patients. In the limited number of cases analysed so far, we found TIAM1 mRNA levels in the DS AML-M7 samples of bone marrow taken in the acute phase of the disease (presentation or relapse, n=8) to be highly significantly raised, nearly threefold, compared to that measured in the remission samples or normal individuals (normals + remissions, n=10).
Keywords Acute DiseaseBone Marrow/ metabolism/pathologyChild, PreschoolChromosomes, Human, Pair 21/ geneticsDown Syndrome/complications/ geneticsGene Expression Regulation, NeoplasticGuanine Nucleotide Exchange FactorsHumansInfantInfant, NewbornKaryotypingLeukemia, Megakaryoblastic, Acute/complications/ geneticsNeoplasm Invasiveness/ geneticsPolymerase Chain ReactionProteins/ geneticsRNA, Messenger/ genetics/metabolismRemission InductionTrisomy
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PMID: 9713998
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IVES, J. H. et al. Increased levels of a chromosome 21-encoded tumour invasion and metastasis factor (TIAM1) mRNA in bone marrow of Down syndrome children during the acute phase of AML(M7). In: Genes, Chromosomes and Cancer, 1998, vol. 23, n° 1, p. 61-66. doi: 10.1002/(sici)1098-2264(199809)23:1<61::aid-gcc9>3.0.co;2-4 https://archive-ouverte.unige.ch/unige:8827

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Deposited on : 2010-07-12

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