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No association between DUP25 and anxiety disorders

Henrichsen, C. N.
Delorme, Richard
Boucherie, Maria
Marelli, Dominique
Bellivier, Franck
Courtet, Philippe
Chabane, Nadia
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Published in American journal of medical genetics. Part B, Neuropsychiatric genetics. 2004, vol. 128B, no. 1, p. 80-83
Abstract Gratacos et al. [2001: Cell 106:367-379] described an interstitial duplication dup(15)q24q26 (DUP25) in patients with anxiety disorders; this duplication was found in approximately 90% of patients and in 7% of controls. In order to determine if DUP25 is present in additional individuals susceptible to panic attacks, we tested 44 patients with anxiety disorders, using probes 251c23 and 216c14 mapping in the 15q24 and 15q26 region. We have not detected any DUP25. Our results suggest that DUP25 is not common in people with anxiety disorders in the population tested here.
Keywords AdolescentAdultAgedAnxiety Disorders/epidemiology/ geneticsCase-Control StudiesChromosomes, Human, Pair 15DNA ProbesFemaleGene DuplicationGene FrequencyGenetic Predisposition to DiseaseHumansIn Situ Hybridization, FluorescenceMaleMiddle AgedMolecular Epidemiology
PMID: 15211637
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HENRICHSEN, C. N. et al. No association between DUP25 and anxiety disorders. In: American journal of medical genetics. Part B, Neuropsychiatric genetics, 2004, vol. 128B, n° 1, p. 80-83. doi: 10.1002/ajmg.b.30037 https://archive-ouverte.unige.ch/unige:8802

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Deposited on : 2010-07-12

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