No association between DUP25 and anxiety disorders

Henrichsen, C. N.; Delorme, Richard; Boucherie, Maria; Marelli, Dominique; Baud, Patrick; Bellivier, Franck; Courtet, Philippe; Chabane, Nadia; Henry, Chantal; Leboyer, Marion; Malafosse, Alain; Antonarakis, Stylianos; Dahoun, Sophie

doi:10.1002/ajmg.b.30037

Scientific article

English

No association between DUP25 and anxiety disorders

ContributorsHenrichsen, C. N.; Delorme, Richard; Boucherie, Maria; Marelli, Dominique; Baud, Patrick; Bellivier, Franck; Courtet, Philippe; Chabane, Nadia; Henry, Chantal; Leboyer, Marion; Malafosse, Alain; Antonarakis, Stylianos; Dahoun, Sophie

Published inAmerican journal of medical genetics. Part B, Neuropsychiatric genetics, vol. 128B, no. 1, p. 80-83

Publication date2004

Abstract

Gratacos et al. [2001: Cell 106:367-379] described an interstitial duplication dup(15)q24q26 (DUP25) in patients with anxiety disorders; this duplication was found in approximately 90% of patients and in 7% of controls. In order to determine if DUP25 is present in additional individuals susceptible to panic attacks, we tested 44 patients with anxiety disorders, using probes 251c23 and 216c14 mapping in the 15q24 and 15q26 region. We have not detected any DUP25. Our results suggest that DUP25 is not common in people with anxiety disorders in the population tested here.

Keywords

Adolescent
Adult
Aged
Anxiety Disorders/epidemiology/ genetics
Case-Control Studies
Chromosomes, Human, Pair 15
DNA Probes
Female
Gene Duplication
Gene Frequency
Genetic Predisposition to Disease
Humans
In Situ Hybridization, Fluorescence
Male
Middle Aged
Molecular Epidemiology

Affiliation

Faculté de médecine / Section de médecine clinique / Département de médecine

Citation (ISO format)

HENRICHSEN, C. N. et al. No association between DUP25 and anxiety disorders. In: American journal of medical genetics. Part B, Neuropsychiatric genetics, 2004, vol. 128B, n° 1, p. 80–83. doi: 10.1002/ajmg.b.30037

Article

Identifiers

PID : unige:8802
DOI : 10.1002/ajmg.b.30037
PMID : 15211637

ISSN of the journal1552-4841

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No association between DUP25 and anxiety disorders

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