Scientific article

Impact of Study Design on Reported Incidences of Acute Mountain Sickness: A Systematic Review

Published inHigh altitude medicine & biology, vol. 16, no. 3, p. 204-215
Publication date2015

Published incidences of acute mountain sickness (AMS) vary widely. Reasons for this variation, and predictive factors of AMS, are not well understood. We aimed to identify predictive factors that are associated with the occurrence of AMS, and to test the hypothesis that study design is an independent predictive factor of AMS incidence. We did a systematic search (Medline, bibliographies) for relevant articles in English or French, up to April 28, 2013. Studies of any design reporting on AMS incidence in humans without prophylaxis were selected. Data on incidence and potential predictive factors were extracted by two reviewers and crosschecked by four reviewers. Associations between predictive factors and AMS incidence were sought through bivariate and multivariate analyses for different study designs separately. Association between AMS incidence and study design was assessed using multiple linear regression.

  • Altitude
  • Altitude Sickness/epidemiology
  • Cohort Studies
  • Data Accuracy
  • Forecasting
  • Humans
  • Incidence
  • Mountaineering
  • Research Design
Citation (ISO format)
WAEBER, Baptiste et al. Impact of Study Design on Reported Incidences of Acute Mountain Sickness: A Systematic Review. In: High altitude medicine & biology, 2015, vol. 16, n° 3, p. 204–215. doi: 10.1089/ham.2015.0022
Main files (1)
Article (Published version)
ISSN of the journal1527-0297

Technical informations

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