Free Fatty Acids Impair FGF21 Action in HepG2 Cells

Asrih, Mohamed; Montessuit, Christophe Albert; Philippe, Jacques; Jornayvaz, François

doi:10.1159/000438540

Scientific article

English

Free Fatty Acids Impair FGF21 Action in HepG2 Cells

ContributorsAsrih, Mohamed; Montessuit, Christophe Albert

; Philippe, Jacques; Jornayvaz, François

Published inCellular physiology and biochemistry, vol. 37, no. 5, p. 1767-1778

Publication date2015

Abstract

Fibroblast growth factor 21 (FGF21) is a key mediator of glucose and lipid metabolism. However, the beneficial effects of exogenous FGF21 administration are attenuated in obese animals and humans with elevated levels of circulating free fatty acids (FFA).

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

Citation (ISO format)

ASRIH, Mohamed et al. Free Fatty Acids Impair FGF21 Action in HepG2 Cells. In: Cellular physiology and biochemistry, 2015, vol. 37, n° 5, p. 1767–1778. doi: 10.1159/000438540

Article (Published version)

Identifiers

PID : unige:87951
DOI : 10.1159/000438540
PMID : 26584278

Journal ISSN1015-8987

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Creation29/08/2016 17:46:00

First validation29/08/2016 17:46:00

Update15/03/2023 00:47:54

Status update15/03/2023 00:47:53

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Free Fatty Acids Impair FGF21 Action in HepG2 Cells

Fibroblast growth factor 21 (FGF21) is a key mediator of glucose and lipid metabolism. However, the beneficial effects of exogenous FGF21 administration are attenuated in obese animals and humans with elevated levels of circulating free fatty acids (FFA).

Technical informations