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Challenges, Progresses, and Promises for Developing Future NADPH Oxidase Therapeutics

Whitehouse, Scott
Published in Antioxidants & Redox Signaling. 2015, vol. 23, no. 5, p. 355-357
Abstract NADPH oxidase (NOX) enzymes show great potential as therapeutic pharmacological targets. This Forum revolves around the roles of specific NOX isoforms in oxidative stress-mediated pathologies, available NOX antagonists/agonists as well as the potential side effects of NOX inhibition and the requisite identification of novel oxidative biomarkers as a measure of NOX activity in patients. In addition, an original article reports the discovery of a novel small molecule NOX2 inhibitor. Finally an attractive and innovative therapeutic approach for modulating NOX activity through the inhibition of the proton channel Hv1 is discussed.
Keywords AnimalsDrug DiscoveryHumansIon Channels/metabolismNADPH Oxidase/therapeutic useOxidative Stress
PMID: 26207329
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Research group Radicaux libres et cellules souches embryonnaires (60)
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BEDARD, Karen, WHITEHOUSE, Scott, JAQUET, Vincent. Challenges, Progresses, and Promises for Developing Future NADPH Oxidase Therapeutics. In: Antioxidants & redox signaling, 2015, vol. 23, n° 5, p. 355-357. doi: 10.1089/ars.2015.6450 https://archive-ouverte.unige.ch/unige:87949

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Deposited on : 2016-10-04

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