en
Scientific article
Editorial
English

Challenges, Progresses, and Promises for Developing Future NADPH Oxidase Therapeutics

Published inAntioxidants & redox signaling, vol. 23, no. 5, p. 355-357
Publication date2015
Abstract

NADPH oxidase (NOX) enzymes show great potential as therapeutic pharmacological targets. This Forum revolves around the roles of specific NOX isoforms in oxidative stress-mediated pathologies, available NOX antagonists/agonists as well as the potential side effects of NOX inhibition and the requisite identification of novel oxidative biomarkers as a measure of NOX activity in patients. In addition, an original article reports the discovery of a novel small molecule NOX2 inhibitor. Finally an attractive and innovative therapeutic approach for modulating NOX activity through the inhibition of the proton channel Hv1 is discussed.

Keywords
  • Animals
  • Drug Discovery
  • Humans
  • Ion Channels/metabolism
  • NADPH Oxidase/therapeutic use
  • Oxidative Stress
Citation (ISO format)
BEDARD, Karen, WHITEHOUSE, Scott, JAQUET, Vincent. Challenges, Progresses, and Promises for Developing Future NADPH Oxidase Therapeutics. In: Antioxidants & redox signaling, 2015, vol. 23, n° 5, p. 355–357. doi: 10.1089/ars.2015.6450
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Article (Published version)
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Identifiers
ISSN of the journal1523-0864
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