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Controversies in the diagnosis of venous thromboembolism

Le Gal, G
Published in Journal of Thrombosis and Haemostasis. 2015, vol. 13 Suppl 1, p. S259-S265
Abstract Over the last decades, important advances have been made in the diagnosis of venous thromboembolism (VTE). Current diagnostic strategies rely on the sequential use of non-invasive diagnostic tests, based on the pretest clinical probability of disease. Diagnostic tests include D-dimer measurement, leg vein compression ultrasonography, chest computed tomography pulmonary angiography, or ventilation perfusion (V/Q) lung scan. The safety and cost-effectiveness of these strategies have been extensively validated. They have been widely implemented in clinical practice and have replaced the historical gold standard diagnostic tests (venography and pulmonary angiography). However, new challenges arise, including a lower clinical suspicion threshold and concerns on potential over-diagnosis of VTE. Moreover, the diagnostic management remains suboptimal in many subgroups of patients with suspected VTE: patients with prior VTE, pregnant women, or elderly patients.
Keywords Biomarkers/bloodDiagnostic Imaging/methodsFibrin Fibrinogen Degradation Products/analysisHumansPredictive Value of TestsPrognosisPulmonary Embolism/blood/diagnosis/therapyRisk AssessmentRisk FactorsVenous Thromboembolism/blood/diagnosis/therapyVenous Thrombosis/blood/diagnosis/therapy
PMID: 26149033
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Research group La maladie thromboembolique veineuse (808)
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LE GAL, G, RIGHINI, Marc Philip. Controversies in the diagnosis of venous thromboembolism. In: Journal of Thrombosis and Haemostasis, 2015, vol. 13 Suppl 1, p. S259-S265. doi: 10.1111/jth.12937 https://archive-ouverte.unige.ch/unige:87943

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Deposited on : 2016-10-04

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