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COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome

Gothelf, Doron
Thompson, Tracy
Hinard, Christine
Penniman, Lauren
Feinstein, Carl
Kwon, Hower
Jin, Shuting
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Published in Nature Neuroscience. 2005, vol. 8, no. 11, p. 1500-1502
Abstract Although schizophrenia is strongly hereditary, there are limited data regarding biological risk factors and pathophysiological processes. In this longitudinal study of adolescents with 22q11.2 deletion syndrome, we identified the catechol-O-methyltransferase low-activity allele (COMT(L)) as a risk factor for decline in prefrontal cortical volume and cognition, as well as for the consequent development of psychotic symptoms during adolescence. The 22q11.2 deletion syndrome is a promising model for identifying biomarkers related to the development of schizophrenia.
Keywords AdolescentAdultAnalysis of VarianceCatechol O-Methyltransferase/ geneticsChromosomes, Human, Pair 22Cognition Disorders/etiology/ geneticsDiGeorge Syndrome/complications/ enzymology/ geneticsFemaleGene DeletionGenetic Predisposition to DiseaseGenotypeHumansLongitudinal StudiesMagnetic Resonance Imaging/methodsMaleNeuropsychological TestsPolymorphism, GeneticPredictive Value of TestsPsychiatric Status Rating ScalesRisk Factors
PMID: 16234808
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Other version: http://www.nature.com/neuro/journal/v8/n11/pdf/nn1572.pdf
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GOTHELF, Doron et al. COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome. In: Nature Neuroscience, 2005, vol. 8, n° 11, p. 1500-1502. https://archive-ouverte.unige.ch/unige:8763

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Deposited on : 2010-07-12

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