Hydrothermal iron ores at Divriği, east Central Anatolia, are contained in two orebodies, the magnetite-rich A-kafa and the limonitic B-kafa (resources of 133.8 Mt with 56% Fe and 0.5% Cu). The magnetite ores are hosted in serpentinites of the Divriği ophiolite at the contact with plutons of the Murmano complex. Hydrothermal biotite from the Divriği A-kafa yield identical weighted mean plateau ages of 73.75 ± 0.62 and 74.34 ± 0.83 Ma (2σ). This biotite represents a late alteration phase, and its age is a minimum age for the magnetite ore. Similar magnetite ores occur at Hasançelebi and Karakuz, south of Divriği. There, the iron ores are hosted in volcanic or subvolcanic rocks, respectively, and are associated with a voluminous scapolite ± amphibole ± biotite alteration. At Hasançelebi, biotite is intergrown with parts of the magnetite, and both minerals formed coevally. The weighted mean plateau ages of hydrothermal biotite of 73.43 ± 0.41 and 74.92 ± 0.39 Ma (2σ), therefore, represent mineralization ages. Hydrothermal biotite from a vein cutting the scapolitized host rocks south of the Hasançelebi prospect has a weighted mean plateau age of 73.12 ± 0.75 Ma (2σ). This age, together with the two biotite ages from the Hasançelebi ores, constrains the minimum age of the volcanic host rocks, syenitic porphyry dikes therein, and the scapolite alteration affecting both rock types. Pyrite and calcite also represent late hydrothermal stages in all of these magnetite deposits. The sulfur isotope composition of pyrite between 11.5 and 17.4‰ δ34S(VCDT) points towards a non-magmatic sulfur source of probably evaporitic origin. Calcite from the Divriği deposit has δ18O(VSMOV) values between +15.1 and +26.5‰ and δ13C(VPDB) values between −2.5 and +2.0‰, which are compatible with an involvement of modified marine evaporitic fluids during the late hydrothermal stages, assuming calcite formation temperatures of about 300°C. The presence of evaporite-derived brines also during the early stages is corroborated by the pre-magnetite scapolite alteration at Divriği, and Hasançelebi-Karakuz, and with paleogeographic and paleoclimatic reconstructions. The data are compatible with a previously proposed genetic model for the Divriği deposit in which hydrothermal fluids leach and redistribute iron from ophiolitic rocks concomitant with the cooling of the nearby plutons.