UNIGE document Scientific Article
previous document  unige:8758  next document
add to browser collection

Language skills in children with velocardiofacial syndrome (deletion 22q11.2)

Mumme, D. L.
Blasey, Christine
Dahoun, S. P.
Reiss, A. L.
Published in The Journal of Pediatrics. 2002, vol. 140, no. 6, p. 753-758
Abstract OBJECTIVE: To further define the language profile of children with velocardiofacial syndrome (VCFS) and explore the influence of parental origin of the deletion on language. STUDY DESIGN: Children and adolescents with VCFS (n = 27) were group-matched for sex, age, and IQ with 27 children and adolescents with idiopathic developmental delay. Fifty-four typically developing control subjects were also included in the analyses investigating word association abilities. RESULTS: Children with VCFS had significantly lower receptive than expressive language skills, a unique finding when compared with IQ-matched control subjects. However, no significant differences in word association were detected. Children with a deletion of paternal origin score significantly higher on receptive language when compared with children with a deletion of maternal origin. CONCLUSIONS: The Clinical Evaluation of Language Fundamentals-III results suggest that children with VCFS show more severe deficits in receptive than expressive language abilities. Language skills of children with VCFS could be influenced by parental origin of the deletion and thus related to neuroanatomic alterations at the deletion site.
Keywords AdolescentChildChromosome DeletionChromosomes, Human, Pair 22/ geneticsCraniofacial Abnormalities/ geneticsDNA Mutational AnalysisFemaleHumansLanguage DevelopmentMaleSpeechSyndromeWord Association Tests
PMID: 12072882
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
(ISO format)
GLASER, Bronwyn et al. Language skills in children with velocardiofacial syndrome (deletion 22q11.2). In: The Journal of Pediatrics, 2002, vol. 140, n° 6, p. 753-758. doi: 10.1067/mpd.2002.124774 https://archive-ouverte.unige.ch/unige:8758

381 hits



Deposited on : 2010-07-12

Export document
Format :
Citation style :