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Ccr4-Not is at the core of the eukaryotic gene expression circuitry

Published in Biochemical Society transactions. 2015, vol. 43, no. 6, p. 1253-1258
Abstract In this mini-review, we summarize our current knowledge about the cross-talk between the different levels of gene expression. We introduce the Ccr4 (carbon catabolite repressed 4)-Not (negative on TATA-less) complex as a candidate to be a master regulator that orchestrates between the different levels of gene expression. An integrated view of the findings about the Ccr4-Not complex suggests that it is involved in gene expression co-ordination. Since the discovery of the Not proteins in a selection for transcription regulators in yeast [Collart and Struhl (1994) Genes Dev. 8: , 525-537], the Ccr4-Not complex has been connected to every step of the mRNA lifecycle. Moreover, it has been found to be relevant for appropriate protein folding and quaternary protein structure by being involved in co-translational protein complex assembly.
Keywords Cell Cycle Proteins/genetics/metabolismEukaryotic Cells/metabolismGene Expression RegulationModels, GeneticMultiprotein Complexes/genetics/metabolismRNA, Messenger/genetics/metabolismRepressor Proteins/genetics/metabolismRibonucleases/genetics/metabolismSaccharomyces cerevisiae/genetics/metabolismSaccharomyces cerevisiae Proteins/genetics/metabolismTranscription Factors/genetics/metabolism
PMID: 26614669
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Research group Caractérisation génétique et biochimique du complexe Ccr4-Not conservé (81)
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VILLANYI, Zoltan, COLLART, Martine. Ccr4-Not is at the core of the eukaryotic gene expression circuitry. In: Biochemical Society transactions, 2015, vol. 43, n° 6, p. 1253-1258. doi: 10.1042/BST20150167 https://archive-ouverte.unige.ch/unige:87429

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Deposited on : 2016-09-16

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