Fibrinogen and the risk of thrombosis

De Moerloose, Philippe; Boehlen, Françoise; Neerman Arbez, Marguerite

doi:10.1055/s-0030-1248720

Scientific article

English

Fibrinogen and the risk of thrombosis

Contributors

De Moerloose, Philippe; Boehlen, Françoise; Neerman Arbez, Marguerite

Published in

Seminars in thrombosis and hemostasis, vol. 36, no. 1, p. 7-17

Publication date

2010

Abstract

Fibrinogen contributes to thrombosis risk in different ways. Indeed, various mutations in the fibrinogen genes predispose to thrombosis. At the same time, high levels of fibrinogen are also associated with thrombotic complications. Although the underlying causative mechanisms are not clear, this most likely involves the associated inflammatory and hypercoagulable states. In the last few years, particular attention has focused on the polymorphisms of fibrinogen genes involved in increased fibrinogen levels or fibrinogen qualitative changes. The association between dysfibrinogenemia and risk of thrombosis is well known, and some mechanisms have been clearly identified. Paradoxically, some patients with either hypofibrinogenemia or afibrinogenemia may also suffer from severe thromboembolic complications. The management of these patients is particularly challenging because they are not only at risk of thrombosis but also of bleeding. This review discusses the various quantitative and qualitative defects of fibrinogen associated with thrombosis, the tests that may predict the thrombotic risk, as well as some preventive or therapeutic approaches.

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Citation (ISO format)

DE MOERLOOSE, Philippe, BOEHLEN, Françoise, NEERMAN ARBEZ, Marguerite. Fibrinogen and the risk of thrombosis. In: Seminars in thrombosis and hemostasis, 2010, vol. 36, n° 1, p. 7–17. doi: 10.1055/s-0030-1248720

Article

Identifiers

PID : unige:8704
DOI : 10.1055/s-0030-1248720
PMID : 20391292

Journal ISSN

0094-6176

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12/07/2010 11:57:34

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12/07/2010 11:57:34

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14/03/2023 15:50:39

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16/12/2024 14:51:37

Fibrinogen and the risk of thrombosis

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation