UNIGE document Scientific Article
previous document  unige:87019  next document
add to browser collection
Title

Apolipoprotein E e4 and cognitive function: A modifiable association? Results from two independent cohort studies

Authors
Perna, Laura
Mons, Ute
Rujescu, Dan
Brenner, Hermann
Published in Dementia and Geriatric Cognitive Disorders. 2016, vol. 41, p. 35-45
Abstract Background: The apolipoprotein E (APOE) e4 genetic polymorphism is a major risk factor for Alzheimer’s disease, hence the possible prevention of its detrimental effects on cognition is of high relevance. Methods: We used linear regression models to assess associations of APOE e4 with cognitive performance in a population-based cohort study (n = 1,434) and in a cohort of patients with coronary heart disease (n = 366), and restricted cubic splines to explore dose-response relationships between serum cholesterol levels and cognition depending on APOE polymorphism. Results: The association of APOE e4 with cognitive function was strongly amplified in the presence of hypercholesterolemia and cardiovascular disease in both independent cohorts; hypercholesterolemia was associated with cognitive function only among APOE e4 carriers in the presence of cardiovascular disease. The interaction effect between APOE genotype and hypercholesterolemia was statistically significant in both cohorts. Conclusions: The detrimental effects of APOE e4 polymorphism on cognition may strongly depend on modifiable risk factors.
Identifiers
Full text
Article (Editor postprint) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Laboratoire du vieillissement cognitif
Cognitive Aging Lab (CAL)
Citation
(ISO format)
PERNA, Laura et al. Apolipoprotein E e4 and cognitive function: A modifiable association? Results from two independent cohort studies. In: Dementia and Geriatric Cognitive Disorders, 2016, vol. 41, p. 35-45. https://archive-ouverte.unige.ch/unige:87019

138 hits

1 download

Update

Deposited on : 2016-09-15

Export document
Format :
Citation style :