UNIGE document Scientific Article
previous document  unige:8694  next document
add to browser collection
Title

Modulations of functional activity in differentiated macrophages are accompanied by early and transient increase or decrease in c-fos gene transcription

Authors
Published in Journal of Immunology. 1987, vol. 139, no. 3, p. 949-955
Abstract Marked changes in c-fos proto-oncogene mRNA level and transcription rate were observed upon modulation of the functional activity of cultured mouse peritoneal macrophages. Cholera toxin (CT), dexamethasone (dex), interferon-gamma (IFN-gamma), concanavalin A (Con A), and endotoxin (LPS) induced changes in mRNA levels and transcription rates of both urokinase-type plasminogen activator and tumor necrosis factor/cachectin genes, the products of which are sensitive indices of macrophage activity. All of these agents also caused rapid and transient changes in c-fos gene expression, either enhancement (CT, dex, and LPS) or decrease (IFN-gamma and Con A). Moreover, inhibition of protein synthesis elicited a transient increase in the level of c-fos gene transcription, suggesting that the transcriptional activity of the c-fos gene is controlled by labile protein repressor(s). Taken together, these results suggest a possible role for the c-fos gene product, a nuclear protein, in the modulation of the functional activity of differentiated macrophages.
Keywords AnimalsCell DifferentiationCells, CulturedCholera Toxin/pharmacologyConcanavalin A/pharmacologyCycloheximide/pharmacologyDexamethasone/pharmacologyEmetine/pharmacologyGene Expression Regulation/ drug effectsGlycoproteins/biosynthesis/geneticsInterferon-gamma/pharmacologyLipopolysaccharides/pharmacologyMacrophages/ physiologyMiceMice, Inbred Strains/genetics/immunologyPlasminogen Activators/biosynthesis/geneticsProto-Oncogene Proteins/ biosynthesis/geneticsProto-Oncogene Proteins c-fosProto-OncogenesRNA, Messenger/biosynthesisRepressor Proteins/biosynthesis/physiologyTranscription, Genetic/drug effectsTumor Necrosis Factor-alphaUrokinase-Type Plasminogen Activator/biosynthesis/genetics
Identifiers
PMID: 3110291
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.jimmunol.org/cgi/reprint/139/3/949.pdf
Structures
Citation
(ISO format)
COLLART, Martine et al. Modulations of functional activity in differentiated macrophages are accompanied by early and transient increase or decrease in c-fos gene transcription. In: Journal of Immunology, 1987, vol. 139, n° 3, p. 949-955. https://archive-ouverte.unige.ch/unige:8694

209 hits

0 download

Update

Deposited on : 2010-07-12

Export document
Format :
Citation style :