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Immunity-related genes and gene families in Anopheles gambiae

Christophides, G. K.
Barillas-Mury, Carolina
Birney, Ewan
Blandin, Stephanie
Blass, Claudia
Brey, P. T.
Collins, F. H.
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Published in Science. 2002, vol. 298, no. 5591, p. 159-165
Abstract We have identified 242 Anopheles gambiae genes from 18 gene families implicated in innate immunity and have detected marked diversification relative to Drosophila melanogaster. Immune-related gene families involved in recognition, signal modulation, and effector systems show a marked deficit of orthologs and excessive gene expansions, possibly reflecting selection pressures from different pathogens encountered in these insects' very different life-styles. In contrast, the multifunctional Toll signal transduction pathway is substantially conserved, presumably because of counterselection for developmental stability. Representative expression profiles confirm that sequence diversification is accompanied by specific responses to different immune challenges. Alternative RNA splicing may also contribute to expansion of the immune repertoire.
Keywords Alternative SplicingAnimalsAnopheles/ genetics/ immunology/metabolism/microbiology/parasitologyApoptosisBacteria/immunologyCatechol Oxidase/metabolismComputational BiologyDrosophila Proteins/chemistry/genetics/metabolismDrosophila melanogaster/genetics/immunology/metabolismEnzyme Precursors/metabolismGene Expression RegulationGenes, InsectGenomeImmunity, InnateInsect Proteins/chemistry/genetics/metabolismMultigene FamilyPeptides/metabolismPhylogenyPlasmodium/immunology/physiologyProtein Structure, TertiarySelection, GeneticSerine Endopeptidases/metabolismSerpins/metabolismSignal Transduction
PMID: 12364793
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Other version: http://www.sciencemag.org/cgi/reprint/298/5591/159.pdf
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CHRISTOPHIDES, G. K. et al. Immunity-related genes and gene families in Anopheles gambiae. In: Science, 2002, vol. 298, n° 5591, p. 159-165. doi: 10.1126/science.1077136 https://archive-ouverte.unige.ch/unige:8689

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Deposited on : 2010-07-12

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