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Atherosclerosis severity is not affected by a deficiency in IL-33/ST2 signaling

Martin, Praxedis Sina
Smith, Dirk E
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Published in Immunity, inflammation and disease. 2015, vol. 3, no. 3, p. 239-246
Abstract Interleukin (IL)-33 is a cytokine of the IL-1 family, which signals through the ST2 receptor. Previous work demonstrated that the systemic administration of recombinant IL-33 reduces the development of atherosclerosis in apolipoprotein E-deficient (ApoE(-/-)) mice by inducing a Th1-to-Th2 shift. The objective of our study was to examine the role of endogenous IL-33 and ST2 in atherosclerosis. ApoE(-/-), IL-33(-/-)ApoE(-/-), and ST2(-/-)ApoE(-/-) mice were fed with a cholesterol-rich diet for 10 weeks. Additionally, a group of ApoE(-/-) mice was injected with a neutralizing anti-ST2 or an isotype control antibody during the period of the cholesterol-rich diet. Atherosclerotic lesion development was measured by Oil Red O staining in the thoracic-abdominal aorta and the aortic sinus. There were no significant differences in the lipid-staining area of IL-33(-/-)ApoE(-/-), ST2(-/-)ApoE(-/-), or anti-ST2 antibody-treated ApoE(-/-) mice, compared to ApoE(-/-) controls. The absence of IL-33 signaling had no major and consistent impact on the Th1/Th2 cytokine responses in the supernatant of in vitro-stimulated lymph node cells. In summary, deficiency of the endogenously produced IL-33 and its receptor ST2 does not impact the development of atherosclerosis in ApoE-deficient mice.
PMID: 26417439
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Article (Published version) (2.2 MB) - public document Free access
Research groups Biologie des cytokines de la famille de l'interleukine-1 (1022)
L'athérosclérose (665)
Mécanisme de l'inflammation articulaire (44)
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MARTIN, Praxedis Sina et al. Atherosclerosis severity is not affected by a deficiency in IL-33/ST2 signaling. In: Immunity, inflammation and disease, 2015, vol. 3, n° 3, p. 239-246. doi: 10.1002/iid3.62 https://archive-ouverte.unige.ch/unige:86875

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Deposited on : 2016-09-07

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