en
Scientific article
Open access
English

An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull

Published inDevelopmental biology, vol. 415, no. 2, p. 261-277
Publication date2016
Abstract

The neurocranium generates most of the craniofacial skeleton and consists of prechordal and postchordal regions. Although development of the prechordal is well studied, little is known of the postchordal region. Here we characterize a signaling hierarchy necessary for postchordal neurocranial development involving Fibroblast growth factor (Fgf) signaling for early specification of mesodermally-derived progenitor cells. The expression of hyaluron synthetase 2 (has2) in the cephalic mesoderm requires Fgf signaling and Has2 function, in turn, is required for postchordal neurocranial development. While Hedgehog (Hh)-deficient embryos also lack a postchordal neurocranium, this appears primarily due to a later defect in chondrocyte differentiation. Inhibitor studies demonstrate that postchordal neurocranial development requires early Fgf and later Hh signaling. Collectively, our results provide a mechanistic understanding of early postchordal neurocranial development and demonstrate a hierarchy of signaling between Fgf and Hh in the development of this structure.

Citation (ISO format)
MCCARTHY, Neil et al. An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull. In: Developmental biology, 2016, vol. 415, n° 2, p. 261–277. doi: 10.1016/j.ydbio.2016.04.005
Main files (1)
Article (Published version)
Identifiers
ISSN of the journal0012-1606
471views
132downloads

Technical informations

Creation08/29/2016 7:41:00 AM
First validation08/29/2016 7:41:00 AM
Update time03/15/2023 12:42:24 AM
Status update03/15/2023 12:42:23 AM
Last indexation05/02/2024 5:44:14 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack