Scientific article

Interventions for treating bisphosphonate-related osteonecrosis of the jaw (BRONJ)

Published inCochrane database of systematic reviews, vol. 2, CD008455
Publication date2016

Bisphosphonate drugs can be used to prevent and treat osteoporosis and to reduce symptoms and complications of metastatic bone disease; however, they are associated with a rare but serious adverse event: osteonecrosis of the maxillary and mandibular bones. This condition is called bisphosphonate-related osteonecrosis of the jaw or BRONJ. BRONJ is diagnosed when people who are taking, or have previously taken, bisphosphonates have exposed bone in the jaw area for more than eight weeks in the absence of radiation treatment. There is currently no "gold standard" of treatment for BRONJ. The three broad categories of intervention are conservative approaches (e.g. mouth rinse, antibiotics), surgical interventions and adjuvant non-surgical strategies (e.g. hyperbaric oxygen therapy, platelet-rich plasma), which can be used in combination.

  • Anti-Bacterial Agents/therapeutic use
  • Bisphosphonate-Associated Osteonecrosis of the Jaw/surgery/therapy
  • Combined Modality Therapy/methods
  • Humans
  • Hyperbaric Oxygenation/methods
  • Mouthwashes/therapeutic use
  • Pain Measurement
  • Randomized Controlled Trials as Topic
  • Standard of Care
  • Time Factors
Citation (ISO format)
ROLLASON, Victoria et al. Interventions for treating bisphosphonate-related osteonecrosis of the jaw (BRONJ). In: Cochrane database of systematic reviews, 2016, vol. 2, p. CD008455. doi: 10.1002/14651858.CD008455.pub2
Main files (1)
Article (Published version)
ISSN of the journal1361-6137

Technical informations

Creation08/26/2016 4:31:00 PM
First validation08/26/2016 4:31:00 PM
Update time03/15/2023 12:42:07 AM
Status update03/15/2023 12:42:07 AM
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