STUDY OBJECTIVE: To evaluate the efficacy of laparoscopic lateral suspension using mesh in patients with pelvic organ prolapse (POP). DESIGN: A prospective cohort study (Canadian Task Force classification II-2). SETTING: A tertiary referral center for operative laparoscopy. PATIENTS: In all, 73 patients with POP were assessed in the preoperative and postoperative stages. The assessment included a description of their functional symptoms and the degree of their POP condition, established according to the Baden-Walker prolapse classification system. The patients were followed in the postoperative stage for a median of 19 (range 12-41) months. INTERVENTIONS: Laparoscopic lateral suspension of pelvic organs using mesh carried out from January 2004 through September 2006. MEASUREMENTS AND MAIN RESULTS: Satisfactory anatomic results were obtained in 64 (87.7%) patients. Neither major complications, nor postoperative pelvic infection were reported. None of the operations required laparotomy. CONCLUSION: Laparoscopic lateral suspension using mesh effectively treats POP with low morbidity.