en
Scientific article
English

Characteristics of sepsis-induced cardiac dysfunction using speckle-tracking echocardiography: a feasibility study

Published inAnaesthesia and intensive care medicine, vol. 44, no. 1, p. 65-76
Publication date2016
Abstract

Septic cardiomyopathy is commonly encountered in patients with severe sepsis and septic shock. This study explores whether novel global and segmental echocardiographic markers of myocardial deformation, using two-dimensional speckle tracking, are associated with adverse sepsis outcomes. We conducted a retrospective observational feasibility study, at a tertiary care centre, of patients admitted to the ICU with a diagnosis of sepsis who underwent an echocardiogram within the first week of sepsis diagnosis. Data were collected on chamber dimensions, systolic and diastolic function, demographics, haemodynamics, and laboratory parameters. Global and segmental left ventricular longitudinal strain (LVLS) and tissue mitral annular displacement (TMAD) were assessed on 12 left ventricular segments and six mitral annulus segments in apical views, respectively. We explored associations of abnormal LVLS and TMAD with duration of mechanical ventilation, hospital length of stay, and mortality. Fifty-four patients were included. Global LVLS was not associated with any of the primary study endpoints. However, reduced systolic LVLS of the basal anterior segment was associated with in-hospital mortality. There was a suggestion that patients with a reduced global TMAD were associated with an increased risk of mortality and a short length of hospital stay but these associations were not statistically significant. Reduced global LVLS was associated with lower ejection fraction. Reduced global TMAD was associated with reduced global and segmental LVLS, reduced left ventricular ejection fraction, and increased left ventricular end-systolic and end-diastolic volumes. Speckle-tracking echocardiography can be performed feasibly in patients in sepsis. Global and segmental left ventricular deformation indices are associated with ejection fraction. Further studies need to evaluate the ability of these new indices to predict sepsis outcomes.

Keywords
  • Adult
  • Aged
  • Echocardiography
  • Feasibility Studies
  • Female
  • Heart Diseases/etiology/physiopathology
  • Humans
  • Male
  • Middle Aged
  • Mitral Valve/physiopathology
  • Retrospective Studies
  • Sepsis/complications/physiopathology
  • Stroke Volume
  • Ventricular Function, Left
Citation (ISO format)
ZAKY, A et al. Characteristics of sepsis-induced cardiac dysfunction using speckle-tracking echocardiography: a feasibility study. In: Anaesthesia and intensive care medicine, 2016, vol. 44, n° 1, p. 65–76.
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1472-0299
476views
3downloads

Technical informations

Creation08/31/2016 1:39:00 PM
First validation08/31/2016 1:39:00 PM
Update time03/15/2023 12:41:46 AM
Status update03/15/2023 12:41:45 AM
Last indexation05/02/2024 5:43:34 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack