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Title

Detection of ATM gene deletion/duplication by multiplex ligation-dependant probe amplification in childhood lymphoid malignancies: a report from the Children's Oncology Group

Authors
Khoshbeen-Boudal, Mary
Betts, David R.
Published in Leukemia Research. 2008, vol. 32, no. 8, p. 1207-13
Abstract ATM gene alterations have been described in various lymphoproliferative malignancies suggesting that ATM contributes to lymphomagenesis. Using multiplex ligation-dependant probe amplification (MLPA), we screened 61 childhood lymphoid malignancies for ATM genomic deletion/duplication. Five samples were found to have a complete deletion or duplication. All the three deletions were found in B-precursor ALL (15%), two were submicroscopic, not detected by standard cytogenetic studies. These observations indicate that as in adult ALL, complete ATM submicroscopic deletion is frequent in childhood B-precursor ALL. As previously hypothesized, these results suggest that ATM may act as a tumor suppressor gene in the pathogenesis of childhood B-precursor ALL.
Keywords Cell Cycle Proteins/geneticsChildDNA-Binding Proteins/geneticsGene AmplificationGene DeletionGene DosageGene DuplicationHumansLymphoma/geneticsProtein-Serine-Threonine Kinases/geneticsTumor Suppressor Proteins/geneticsYohimbine
Identifiers
PMID: 18261794
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Research group Groupe Ozsahin Ayse Hulya (onco-hémato pédiatrie) (889)
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GUMY PAUSE, Fabienne et al. Detection of ATM gene deletion/duplication by multiplex ligation-dependant probe amplification in childhood lymphoid malignancies: a report from the Children's Oncology Group. In: Leukemia Research, 2008, vol. 32, n° 8, p. 1207-13. https://archive-ouverte.unige.ch/unige:866

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Deposited on : 2009-02-20

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