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Title

Detection of ATM gene deletion/duplication by multiplex ligation-dependant probe amplification in childhood lymphoid malignancies: a report from the Children's Oncology Group
Authors
Gumy Pause, Fabienne
Ozsahin, Ayse Hulya
Khoshbeen-Boudal, Mary
Betts, David R.
Maillet, Philippe
Sappino, Pascal
Published in Leukemia Research. 2008, vol. 32, no. 8, p. 1207-13
Abstract ATM gene alterations have been described in various lymphoproliferative malignancies suggesting that ATM contributes to lymphomagenesis. Using multiplex ligation-dependant probe amplification (MLPA), we screened 61 childhood lymphoid malignancies for ATM genomic deletion/duplication. Five samples were found to have a complete deletion or duplication. All the three deletions were found in B-precursor ALL (15%), two were submicroscopic, not detected by standard cytogenetic studies. These observations indicate that as in adult ALL, complete ATM submicroscopic deletion is frequent in childhood B-precursor ALL. As previously hypothesized, these results suggest that ATM may act as a tumor suppressor gene in the pathogenesis of childhood B-precursor ALL.
Keywords Cell Cycle Proteins/genetics — Child — DNA-Binding Proteins/genetics — Gene Amplification — Gene Deletion — Gene Dosage — Gene Duplication — Humans — Lymphoma/genetics — Protein-Serine-Threonine Kinases/genetics — Tumor Suppressor Proteins/genetics — Yohimbine
Identifiers
PMID: 18261794
Full text
Article (Author postprint) (391 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.sciencedirect.com/science/article/pii/S0145212608000039
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Faculté de médecine / Section de médecine clinique / Département de pédiatrie
Research group Groupe Ozsahin Ayse Hulya (onco-hémato pédiatrie) (889)
Citation
(ISO format) 		GUMY PAUSE, Fabienne et al. Detection of ATM gene deletion/duplication by multiplex ligation-dependant probe amplification in childhood lymphoid malignancies: a report from the Children's Oncology Group. In: Leukemia Research, 2008, vol. 32, n° 8, p. 1207-13. https://archive-ouverte.unige.ch/unige:866

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Deposited on : 2009-02-20

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