

Other version: http://www.sciencedirect.com/science/article/pii/S0145212608000039
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Detection of ATM gene deletion/duplication by multiplex ligation-dependant probe amplification in childhood lymphoid malignancies: a report from the Children's Oncology Group |
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Published in | Leukemia research. 2008, vol. 32, no. 8, p. 1207-13 | |
Abstract | ATM gene alterations have been described in various lymphoproliferative malignancies suggesting that ATM contributes to lymphomagenesis. Using multiplex ligation-dependant probe amplification (MLPA), we screened 61 childhood lymphoid malignancies for ATM genomic deletion/duplication. Five samples were found to have a complete deletion or duplication. All the three deletions were found in B-precursor ALL (15%), two were submicroscopic, not detected by standard cytogenetic studies. These observations indicate that as in adult ALL, complete ATM submicroscopic deletion is frequent in childhood B-precursor ALL. As previously hypothesized, these results suggest that ATM may act as a tumor suppressor gene in the pathogenesis of childhood B-precursor ALL. | |
Keywords | Cell Cycle Proteins/genetics — Child — DNA-Binding Proteins/genetics — Gene Amplification — Gene Deletion — Gene Dosage — Gene Duplication — Humans — Lymphoma/genetics — Protein-Serine-Threonine Kinases/genetics — Tumor Suppressor Proteins/genetics — Yohimbine | |
Identifiers | PMID: 18261794 | |
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![]() ![]() Other version: http://www.sciencedirect.com/science/article/pii/S0145212608000039 |
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Research group | Groupe Ozsahin Ayse Hulya (onco-hémato pédiatrie) (889) | |
Citation (ISO format) | GUMY PAUSE, Fabienne et al. Detection of ATM gene deletion/duplication by multiplex ligation-dependant probe amplification in childhood lymphoid malignancies: a report from the Children's Oncology Group. In: Leukemia research, 2008, vol. 32, n° 8, p. 1207-13. doi: 10.1016/j.leukres.2007.12.012 https://archive-ouverte.unige.ch/unige:866 |