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Detection of ATM gene deletion/duplication by multiplex ligation-dependant probe amplification in childhood lymphoid malignancies: a report from the Children's Oncology Group

Publié dansLeukemia research, vol. 32, no. 8, p. 1207-1213
Date de publication2008
Résumé

ATM gene alterations have been described in various lymphoproliferative malignancies suggesting that ATM contributes to lymphomagenesis. Using multiplex ligation-dependant probe amplification (MLPA), we screened 61 childhood lymphoid malignancies for ATM genomic deletion/duplication. Five samples were found to have a complete deletion or duplication. All the three deletions were found in B-precursor ALL (15%), two were submicroscopic, not detected by standard cytogenetic studies. These observations indicate that as in adult ALL, complete ATM submicroscopic deletion is frequent in childhood B-precursor ALL. As previously hypothesized, these results suggest that ATM may act as a tumor suppressor gene in the pathogenesis of childhood B-precursor ALL.

Mots-clés
  • Cell Cycle Proteins/genetics
  • Child
  • DNA-Binding Proteins/genetics
  • Gene Amplification
  • Gene Deletion
  • Gene Dosage
  • Gene Duplication
  • Humans
  • Lymphoma/genetics
  • Protein-Serine-Threonine Kinases/genetics
  • Tumor Suppressor Proteins/genetics
  • Yohimbine
Citation (format ISO)
GUMY PAUSE, Fabienne et al. Detection of ATM gene deletion/duplication by multiplex ligation-dependant probe amplification in childhood lymphoid malignancies: a report from the Children’s Oncology Group. In: Leukemia research, 2008, vol. 32, n° 8, p. 1207–1213. doi: 10.1016/j.leukres.2007.12.012
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Article (Accepted version)
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ISSN du journal0145-2126
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Création19.02.2009 15:22:00
Première validation19.02.2009 15:22:00
Heure de mise à jour14.03.2023 15:00:48
Changement de statut14.03.2023 15:00:48
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