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Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21

Dombroski, B. A.
Nath, S. K.
Lasseter, V. K.
Wolyniec, P. S.
Nestadt, G.
Thornquist, M.
Ullrich, G.
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Published in Nature Genetics. 1998, vol. 20, no. 1, p. 70-73
Abstract Schizophrenia is a common disorder characterized by psychotic symptoms; diagnostic criteria have been established. Family, twin and adoption studies suggest that both genetic and environmental factors influence susceptibility (heritability is approximately 71%; ref. 2), however, little is known about the aetiology of schizophrenia. Clinical and family studies suggest aetiological heterogeneity. Previously, we reported that regions on chromosomes 22, 3 and 8 may be associated with susceptibility to schizophrenia, and collaborations provided some support for regions on chromosomes 8 and 22 (refs 9-13). We present here a genome-wide scan for schizophrenia susceptibility loci (SSL) using 452 microsatellite markers on 54 multiplex pedigrees. Non-parametric linkage (NPL) analysis provided significant evidence for an SSL on chromosome 13q32 (NPL score=4.18; P=0.00002), and suggestive evidence for another SSL on chromosome 8p21-22 (NPL=3.64; P=0.0001). Parametric linkage analysis provided additional support for these SSL. Linkage evidence at chromosome 8 is weaker than that at chromosome 13, so it is more probable that chromosome 8 may be a false positive linkage. Additional putative SSL were noted on chromosomes 14q13 (NPL=2.57; P=0.005), 7q11 (NPL=2.50, P=0.007) and 22q11 (NPL=2.42, P=0.009). Verification of suggestive SSL on chromosomes 13q and 8p was attempted in a follow-up sample of 51 multiplex pedigrees. This analysis confirmed the SSL in 13q14-q33 (NPL=2.36, P=0.007) and supported the SSL in 8p22-p21 (NPL=1.95, P=0.023).
Keywords AdultChromosomes, Human, Pair 13Chromosomes, Human, Pair 8Disease SusceptibilityFemaleGenes, DominantHumansLinkage (Genetics)Lod ScoreMaleMicrosatellite RepeatsModels, GeneticSchizophrenia/ genetics
PMID: 9731535
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Other version: http://www.nature.com/ng/journal/v20/n1/pdf/ng0998_70.pdf
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BLOUIN, Jean-Louis et al. Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. In: Nature Genetics, 1998, vol. 20, n° 1, p. 70-73. doi: 10.1038/1734 https://archive-ouverte.unige.ch/unige:8646

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